子宫内膜息肉发病机制研究进展

Research progress in the pathogenesis of endometrial polyps

子宫内膜息肉(EPs)是一种局部子宫内膜腺体和间质过度生长的子宫内膜良性病变,主要表现为异常子宫出血、不孕等,且EPs切除术后易复发,影响女性的生殖健康,因此明确EPs发病机制尤为重要。本文从遗传学因素、细胞增殖与凋亡失衡、激素失衡、炎性因子分泌异常以及免疫细胞比例失衡方面综述了EPs的发病机制,以期为更深入的机制研究提供更多参考。

Endometrial polyps(EPs)are benign endometrial lesions involving excessive growth of local endometrial glands and stroma,manifested mainly as abnormal uterine bleeding and infertility.EPs are prone to recurrence after resection,affecting women’s reproductive health.For this reason,elucidating the pathogenesis of EPs is of particular importance.This article reviews the pathogenesis of EPs from the perspectives of genetic factors,imbalance between cell proliferation and apoptosis,hormonal imbalance,abnormal secretion of inflammatory factors,and imbalance in the proportion of immune cells,in order to provide a reference for more insights of mechanism research.