异烟耕雾化吸入治疗喉结核的临床观察

Clinical observation of isoniazid nebulized inhalation in the treatment of laryngea tuberculosis

目的探究异烟肼雾化吸入治疗喉结核的临床效果。方法采用随机抽样法纳入60例喉结核患者,均为本院2022年1月-2023年12月时期收治,以动态随机化方法将纳入患者分入两组,各30例,对照组给予常规抗结核治疗,观察组联合异烟肼雾化吸入治疗,比较两组治疗效果、症状评分、实验室指标水平。结果观察组治疗总有效率93.33%更高(P<0.05)。治疗后,观察组咳嗽、声音嘶哑、咽喉疼痛、咽喉充血水肿4项症状评分均更低(P<0.05)。治疗后,观察组测定白细胞介素-10(IL-10)、转化生长因子β1(TGF-β1)指标值均更低(P<0.05)。结论异烟肼雾化吸入治疗喉结核整体效果理想,同时也能更好改善临床症状、IL-10及TGF-β1水平,值得推荐和采用。然而,在实际应用中,仍需进一步开展临床研究,完善治疗方案,以确保患者的安全和疗效。

Objective To explore the clinical effect of isoniazid aerosol inhalation in the treatment of laryngeal tuberculosis.Methods A total of 60 patients with laryngeal tuberculosis were randomly selected from our hospital from January 2022 to December 2022.The patients were 2023 into two groups,30 in each group,the control group was treated with routine anti-tuberculosis therapy,and the observation group was treated with isoniazid atomization inhalation.The therapeutic effects,symptom scores and laboratory indexes were compared between the two groups.Results The total effective rate of the observation group was 93.33%and higher than that of the control group(p<0.05).After treatment,the scores of cough,hoarseness,sore throat,congestion and edema of throat in the observation group were lower than those in the control group(p<0.05).After treatment,the interleukin of Il-10 and TGF-β1 in the observation group were lower than those in the control group(p<0.05).Conclusion Isoniazid nebulized inhalation is effective in the treatment of laryngeal tuberculosis,and can improve the clinical symptoms,IL-10 and TGF-B 1 levels.However,in practice,it is still necessary to carry out further clinical research and improve the treatment to ensure the safety and efficacy of patients.