中药红芪饮片治疗急性下壁心肌梗死经皮冠脉介入术后患者的疗效分析

Study the effect of Hedysari Radix Chinese Herbal pieces treatment in acute inferior myocardial infarction patients undergoing percutaneous coronary intervention

目的评价中药红芪饮片对急性下壁心肌梗死(心梗)经皮冠脉介入术(PCI)后患者的疗效。方法选择2020年3月31日至2023年3月31日石家庄人民医院心内科收治的200例急性下壁心梗行急诊PCI患者作为研究对象。按随机数字表法将患者分为对照组和治疗组,每组100例。对照组给予PCI后常规治疗,患者每日上午及下午各饮用温水500 mL,连续服用至术后30 d;治疗组在术后上午及下午将红芪饮片10 g加入500 mL沸水中冲泡凉温后饮用,连续服用至术后30 d。观察两组患者术后1~5 d血压、多巴胺用药量和使用持续时间,以及30 d内主要心血管不良事件(MACE,包括心脏死亡、心梗、心力衰竭、再入院)和不良反应发生率,并采用躯体化症状自评量表(SSS)评价患者的临床症状改善情况。结果治疗组多巴胺用量较对照组明显减少(mg:960.4±287.9比1160.4±610.5,P<0.05),多巴胺使用持续时间较对照组明显缩短(h:60.7±16.9比71.6±20.4,P<0.05)。治疗组患者PCI后1 d起收缩压明显高于对照组〔mmHg(1 mmHg≈0.133 kPa):96.8±19.5比90.2±11.1,P<0.05〕,持续到术后5 d(mmHg:106.3±14.4比99.7±13.9,P<0.05),两组舒张压变化不明显;术后30 d内治疗组MACE发生率明显低于对照组〔4.0%(4/100)比13.0%(13/100),P<0.05〕,SSS评分亦明显低于对照组(分:31.56±11.58比40.72±18.67,P<0.05)。结论急性下壁心梗PCI术后患者应用中药红芪饮片可明显改善临床疗效。

Objective To analyze the effect of Hedysari Radix Chinese herbal pieces treatment in acute inferior myocardial infarction patients undergoing percutaneous coronary intervention(PCI).Methods A total of 200 patients with acute inferior myocardial infarction undergoing emergency PCI admitted to department of cardiology of Shijiazhuang People's Hospital from March 31,2020 to March 31,2023 were selected as the study objects.The patients were randomly divided into a control group and a treatment group according to a digital random table method.The control group received routine treatment after PCI,and the patients drank 500 mL of warm water in the morning and afternoon every day,continuing this regimen for up to 30 days post-surgery.The treatment group took 10 g of Hedysari Radix Chinese Herbal pieces in 500 mL of boiling water in the morning and afternoon,soaking it and drinking it coolly and temperately,continuing to take it until 30 days after surgery.Blood pressure,Dopamine dosage,and duration were observed in all patients on 1-5 days after surgery.Major adverse cardiovascular event(MACE),such as cardiac death,myocardial infarction,heart failure,and re-admission were tracked in all patients within 30 days,and adverse reactions and clinical symptom improvement were followed up,using the somatic self-rating scale(SSS).Results The total Dopamine dose in the treatment group was significantly lower than that in the control group(mg:960.4±287.9 vs.1160.4±610.5,P<0.05),and the duration of use was significantly shorter than that in the control group(hours:60.7±16.9 vs.71.6±20.4,P<0.05).The systolic blood pressure in the treatment group was significantly higher than that in the control group at 1 day after PCI[mmHg(1 mmHg≈0.133 kPa):96.8±19.5 vs.90.2±11.1,P<0.05],until 5 days after PCI(mmHg:106.3±14.4 vs.99.7±13.9,P<0.05),while the changes in diastolic blood pressure were not significant in both groups.The incidence of MACE in the treatment group was significantly lower than that in the control group within 30 days after PCI[4.0%(4/100)vs.13.0%(13/100),P<0.05],and the SSS score was also significantly lower than that in the control group(31.56±11.58 vs.40.72±18.67,P<0.05).Conclusion The effect of Hedysari Radix Chinese herbal pieces treatment can significantly improve clinical efficacy without significant adverse reactions.