慢性肝病患者预后影响因素分析

Analysis of factors influencing the prognosis of patients with chronic liver disease

目的探讨影响慢性肝病(CLD)患者预后的相关因素。方法选择2016年6月至2017年6月驻马店市中心医院收治并完成随访的98例CLD患者为研究对象,以是否发生死亡作为结局指标,将患者分为死亡组(n=30)和非死亡组(n=68)。采用单因素和多因素logistic回归分析影响CLD患者预后的危险因素。结果CLD患者的体质量指数(BMI)、营养风险筛查量表2002(NRS 2002)评分、是否合并肌少症(SAR)以及血清白蛋白、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)水平与其预后有关(P<0.05)。多因素logistic回归分析结果显示,NRS 2002评分≥3分、合并SAR和血清白蛋白水平降低、ALT水平升高、AST水平升高均是影响CLD患者预后的独立危险因素(P<0.05)。结论NRS 2002评分≥3分、合并SAR和血清白蛋白水平降低、ALT水平升高、AST水平升高的CLD患者死亡风险较高。

Objective To explore the risk factors for the prognosis of patients with chronic liver disease(CLD).Methods Ninety-eight CLD patients admitted to Zhumadian Central Hospital and completed follow-ups from June 2016 to June 2017 were selected as the research subjects.The patients were divided into a death group(n=30)and a non-death group(n=68),with death or not as the outcome indicator.Univariate and multivariate logistic regression were used to analyze the risk factors for the prognosis of CLD patients.Results Body mass index(BMI),nutritional risk screening 2002(NRS 2002)score,sarcopenia(SAR),and serum albumin,alanine transaminase(ALT),and aspartate transaminase(AST)levels of patients with CLD were associated with their prognosis(P<0.05).Multivariate logistic regression analysis showed that NRS 2002 score≥3,comorbid SAR,reduced serum albumin level,increased ALT level,and increased AST level were independent risk factors for the prognosis of CLD patients(P<0.05).Conclusion CLD patients with NRS 2002 score≥3,comorbid SAR,reduced serum albumin level,elevated ALT level,and elevated AST level are at higher risk of death.