血小板聚集功能检测在急性缺血性脑卒中患者个体化治疗中的作用

Role of platelet aggregation function detection in individualized treatment of patients with acute ischemic stroke

目的 探讨血小板聚集功能检测在急性缺血性脑卒中患者个体化治疗中的作用。方法 选取2022年7月至2023年7月山东省临沂市第三人民医院收治的360例急性缺血性脑卒中患者为研究对象,按随机数字表法分为两组,每组180例。对照组给予个体化治疗,试验组在个体化治疗期间进行血小板聚集功能检测,根据检测结果调整治疗方案,治疗7 d。比较两组治疗前后的血小板聚集率、美国国立卫生研究院卒中量表(NIHSS)和Barthel指数评分,比较两组治疗效果及并发症发生率。结果 治疗后,两组血小板聚集率、NIHSS评分均低于治疗前,Barthel指数评分高于治疗前,且试验组血小板聚集率、NIHSS评分均低于对照组,Barthel指数评分高于对照组,差异有统计学意义(P<0.05)。试验组治疗效果优于对照组,并发症的总发生率低于对照组,差异有统计学意义(P<0.05)。结论在急性缺血性脑卒中患者个体化治疗中,血小板聚集功能检测的应用效果显著,有利于优化治疗方案,降低血小板聚集率,减轻神经功能缺损程度,增强日常生活能力。

Objective To discuss the role of platelet aggregation function detection in individualized treatment of patients with acute ischemic stroke.Methods A total of 360 patients with acute ischemic stroke admitted to Linyi Third People’s Hospital of Shandong Province from July 2022 to July 2023 were selected as study objects and divided into two groups according to random number table method,with 180 patients in each group.The control group was given individualized treatment,and the experimental group was given platelet aggregation function detection during individualized treatment,and treatment plan was adjusted according to detection results,treatment lasted for seven days.Platelet aggregation rate,National Institutes of Health stroke scale(NIHSS)and Barthel index scores between two groups before and after treatment were compared.Treatment effect and complications were compared between two groups.Results After treatment,platelet aggregation rate and NIHSS scores of two groups were lower than before treatment,and Barthel index scores of two groups were higher than before treatment,and platelet aggregation rate and NIHSS scores of the experimental group were lower than those of the control group,Barthel index scores of the experimental group were higher than those of the control group,the differences were statistically significant(P<0.05).Treatment effect of the experimental group was better than that of the control group,and total incidence rate of complications in the experimental group was lower than that in the control group,the differences were statistically significant(P<0.05).Conclusion In individualized treatment of acute ischemic stroke patients,application effect of platelet aggregation function detection is significant,which is conducive to optimizing treatment plan,reducing platelet aggregation rate,alleviating degree of neurological impairment,and enhancing ability of daily life.