糖尿病终末期肾病血液透析患者相关生活质量影响因素分析

Analysis of factors affecting quality of life associated with haemodialysis patients with diabetic end-stage renal disease

目的分析糖尿病终末期肾病血液透析患者相关生活质量影响因素。方法本研究回顾性分析2020年1月至2023年2月南京医科大学附属淮安第一医院血液净化中心收治的105例糖尿病终末期肾病行血液透析患者资料,采用肾脏病生存质量简表(KDQOL-SFTM1.3)统计糖尿病终末期肾病患者的生活质量实际得分情况,并通过多元线性回归分析其相关生活质量影响因素。结果本研究患者生活质量处于KDQOL-SFTM1.3量表的中低水平;不同年龄、费用支付方式、血清白蛋白、血磷、血钙、血清肌酐、估算肾小球滤过率、甲状旁腺激素、C反应蛋白、透析充分性、空腹血糖、餐后2 h血糖、糖化血红蛋白水平的糖尿病终末期肾病行血液透析患者KDQOL-SFTM1.3量表评分比较,差异有统计学意义(P<0.05)。多元线性回归结果显示,年龄(β=-0.176)、血清白蛋白(β=-0.247)、透析充分性(β=-0.160)、C反应蛋白(β=0.272)、糖化血红蛋白(β=0.516)为影响糖尿病终末期肾病血液透析患者相关生活质量影响因素(P<0.05)。结论糖尿病终末期肾病血液透析患者的生活质量主要受年龄、血清白蛋白、透析充分性、C反应蛋白、糖化血红蛋白因素影响。

Objective To analyze the factors affecting quality of life associated with haemodialysis patients with diabetic end-stage renal disease.Methods This study retrospectively analysed the data of 105 patients with diabetic end-stage renal disease undergoing haemodialysis admitted to Blood Purification Center,the Affiliated Huaian No.1 People’s Hospital of Nanjing Medical University from January 2020 to February 2023.The actual quality of life scores of diabetic patients with end-stage renal disease were counted using the kidney disease quality life short form1.3(KDQOL-SFTM1.3),and their associated quality of life influencing factors were analysed by multiple linear regression.Results The quality of life of the patients in this study was at a low to moderate level on the KDQOL-SFTM1.3 scale.There were significant differences in KDQOL-SFTM1.3 scores in patients with diabetic end-stage renal disease undergoing hemodialysis with different age,cost payment method,serum albumin,serum phosphorus,serum calcium,serum creatinine,estimated glomerular filtration rate,parathyroid hormone,C-reactive protein,adequacy of dialysis,fasting glucose,postprandial 2 h glucose,and glycated haemoglobin levels(P<0.05).Multiple linear regression results show that Age(β=-0.176),serum albumin(β=-0.247),dialysis adequacy(β=-0.160),C-reactive protein(β=0.272),and glycated hemoglobin(β=0.516)were the factors influencing the quality of life of patients with diabetic end-stage renal disease on hemodialysis(P<0.05).Conclusion Age,serum albumin,dialysis adequacy,C-reactive protein,and hemoglobin affect the quality of life of patients with diabetic end-stage renal disease on hemodialysis.