静电纺海藻酸钠复合纳米纤维膜制备及其性能

Preparation and performance of electrospun sodium alginate composite nanofiber membranes

针对现有创伤敷料在促伤口愈合及防粘连方面存在的不足,采用静电纺丝技术,以去离子水为溶剂,选用生物相容性材料海藻酸钠进行制备,通过分析溶液电导率、纤维形态及直径分布,优化溶液配比,成功制得具有良好生物相容性、可降解性和高比表面积的海藻酸钠/聚环氧乙烷/聚乙烯吡咯烷酮复合纳米纤维膜。结果显示:当海藻酸钠与聚环氧乙烷质量比为1∶4,海藻酸钠/聚环氧乙烷总质量分数为4%,聚乙烯吡咯烷酮占溶质总质量的10%时,所得复合纳米纤维膜形貌均匀,纤维直径约为240 nm;经氯化钙质量分数为3.0%的无水乙醇溶液交联处理24 h后,复合纳米纤维膜的吸液倍率达到1050.80%,质量损失率为40.63%,显著提升了其耐水性和结构稳定性,展现了在创伤修复领域的应用潜力。

Objective This study aimed to harness the biocompatibility,biodegradability,and anti-adhesion properties of sodium alginate(SA)for potential use in wound dressings.Utilizing environmentally friendly deionized water as a solvent,a composite nanofiber membrane of SA,polyethylene oxide(PEO),and polyvinylpyrrolidone(PVP)was fabricated through a modified small linear trough electrospinning device.The research focused on optimizing the solution′s conductivity,fiber morphology,and diameter distribution of the spinning solution to enhance the spinnability of the SA solution and improve the functional properties of the final membrane.Method The optimal solution mixture was determined through the analysis of solution conductivity,fiber morphology,and diameter distribution.The prepared nanofiber membranes were crosslinked by 3.0%anhydrous ethanol solution of calcium chloride(CaCl_(2))for varying durations(0,2,4,8,12,24 h).After post-treatment,the samples were systematically analyzed for microscopic morphology,chemical structure,swelling behavior,and structural stability to evaluate the effects of cross-linking on membrane properties.Results With a mass ratio of 1∶4 between SA and PEO,4%total solute mass fraction,and PVP constituting 10%of the total solute mass,the SA/PEO/PVP composite nanofiber membranes exhibited uniform morphology with fibers averaging 240 nm in diameter and forming a three-dimensional interwoven network.This network structure was crucial for achieving significant mechanical strength and durability.Cross-linking for 24 h resulted in enhanced water resistance and structural stability,with a swelling ratio of 1050.80%and a mass loss rate of 40.63%,indicating superior physical properties.Conclusion The study successfully developed SA/PEO/PVP composite nanofiber membranes with excellent morphology and enhanced performance after CaCl_(2)cross-linking.The introduction of PEO and PVP not only improved the spinnability of SA but also contributed to the compatibility within the composite,underscoring the potential of these membranes as substrates for wound healing applications.This research emphasizes the innovation of using deionized water as a solvent in a non-toxic spinning process,addressing environmental concerns related to organic solvents.This provides strong evidence for promoting wound healing in accordance with the principles of moist wound healing and offers new insights and directions for the development of advanced wound care solutions.