微小RNA-133在心脏重构中的作用及机制研究进展

Research Progress on the Role and Mechanism of MicroRNA-133 in Cardiac Remodeling

心脏重构是心血管疾病发展的关键病理进程,根据其导致心脏功能障碍的机制分为结构重构、电重构及能量代谢重构。微小RNA是一类高度保守的非编码内源小RNA,在细胞内发挥多种调控作用。大量研究证实miR-133是在心脏中高表达且与心脏重构密切相关的的微小RNA之一,miR-133通过调控靶基因的表达,介导相关信号通路的激活或抑制,参与心肌细胞和心肌成纤维细胞增殖、分化及心脏电生理进程。本文以心脏重构的3种不同病理进程为切入点探讨miR-133发挥的关键作用及潜在机制,以期为阐明心脏重构的病理机制及以核酸为基础的药物研发提供新思路。

Cardiac remodeling is a key pathological process in the development of cardiovascular diseases.According to the mechanisms that lead to cardiac dysfunction,cardiac remodeling can be divided into structural remodeling,electrical remodeling and energy metabolism remodeling.MicroRNAs(miRNAs)are highly conserved non-coding endogenous small RNAs that play a variety of regulatory roles in cells.A large number of studies have confirmed that miR-133 is one of the micrornas highly expressed in the heart and closely related to cardiac remodeling.By regulating the expression of target genes,miR-133 mediates the activation or inhibition of related signaling pathways,and participates in the proliferation,differentiation and cardiac electrophysiological processes of cardiomyocytes and myocardial fibroblasts.In this paper,three different pathologic processes of cardiac remodeling were taken as the breakthrough point to explore the key role and potential mechanism of miR-133,in order to provide new ideas for understanding the mechanism of cardiac remodeling and nucleic acid-based drug development.