驱动基因阴性非小细胞肺癌脑转移放射治疗的研究进展

Research progress in radiotherapy for brain metastases from driver gene-negative non-small cell lung cancer

肺癌的发病率及死亡率居全球第一,非小细胞肺癌(NSCLC)是肺癌主要的病理类型,驱动基因阴性NSCLC占比较大。当伴有脑转移时,放疗是除手术以外首选的局部治疗手段,广泛应用于临床实践。随着技术和药物的不断更新,脑转移患者的生存期普遍被延长。精准治疗时代背景下,放疗的理念及技术朝着精准、多元化方向发展。本文将对放疗技术的更迭以及与其他治疗手段的联合应用进行综述,为临床工作中制订驱动基因阴性NSCLC脑转移患者的放疗方案提供参考。

The incidence and mortality of lung cancer rank first among malignant tumors in the world worldwide.Non-small cell lung cancer(NSCLC)is the main pathological type,with a significant proportion being driver gene-negative NSCLC.When accompanied by brain metastasis,radiotherapy is the optimal local therapy,apart from surgery,and which is widely used applied in clinical practice.With the continuous development of technology and drugs,the survival of patients with brain metastases has been generally improvedprolonged.In the era of precision medicine,the concept and technology of radiotherapy are evolving towards precision and diversification.In this article,the evolution of radiotherapy techniques and its combined application with other treatment methods were reviewed,aiming to provide references for the selection of radiotherapy protocol for driver gene-negative NSCLC patients with brain metastases in clinical practice.