那屈肝素钙联合快速康复对恶性肿瘤患者术后下肢深静脉血栓的预防作用

Prophylactic effect of nardraparin calcium combined with rapid rehabilitation on postoperative deep vein thrombosis of lower extremity in patients with malignant tumor

目的探讨那屈肝素钙联合快速康复对恶性肿瘤患者术后下肢深静脉血栓(DVT)的预防作用。方法收集2022年1月至2023年12月于中国人民解放军战略支援部队特色医学中心接受手术治疗的210例恶性肿瘤患者的临床资料,按照住院期间下肢DVT的预防策略不同将其分为联合组(n=109,采用那屈肝素钙联合快速康复干预)和对照组(n=101,仅接受那屈肝素钙预防干预)。比较两组患者术后住院期间下肢DVT发生率、凝血功能指标、出血率、感染率。结果两组患者手术时间、术中出血量比较,差异无统计学意义(P﹥0.05)。联合组患者术中低体温发生率低于对照组患者,差异有统计学意义(P﹤0.05)。联合组患者下肢DVT发生率为1.8%(2/109),低于对照组患者的8.9%(9/101),差异有统计学意义(P﹤0.05)。两组患者凝血酶原时间、活化部分凝血活酶时间、出血率、吻合口瘘发生率比较,差异均无统计学意义(P﹥0.05)。结论那屈肝素钙联合快速康复可安全有效降低恶性肿瘤患者术后发生下肢DVT的风险,值得推广。

Objective To observe the preventive effect of nadroparin calcium combined with rapid rehabilitation on postoperative deep vein thrombosis(DVT)in patients with malignant tumors.Method Clinical data of 210 patients with malignant tumors who received surgical treatment at the Strategic Support Force Characteristic Medical Center of PLA from January 2022 to December 2023 were collected.According to different prevention strategies for DVT of lower extremity during hospitalization,they were divided into combination group(n=109,given nardraparin calcium combined with rapid rehabilitation intervention)and control group(n=101,only given nardraparin calcium prophylactic intervention).The incidence of lower extremity DVT,coagulation function index,bleeding rate and infection rate were compared between the two groups during postoperative hospitalization.Result There were no statistically significant differences in operation time and blood loss between the two groups(P>0.05).The incidence of intraoperative hypothermia in combination group was lower than that in control group,the difference was statistically significant(P<0.05).The incidence of lower extremity DVT in combination group was 1.8%(2/109),lower than that in control group 8.9%(9/101),the difference was statistically significant(P<0.05).There were no significant differences in prothrombin time,activated partial thrombin time,bleeding rate and incidence of anastomotic fistula between two groups(P>0.05).Conclusion Nardraparin calcium combined with rapid rehabilitation can safely and effectively reduce the risk of postoperative DVT in patients with malignant tumors,and it is worth promoting.