我国服刑人员心理健康水平对前额叶皮层激活的影响:来自功能性近红外的证据

Effects of Mental Health Level on Prefrontal Cortex Activation in Chinese Prison Inmates:Evidence from Functional Near-infrared Spectroscopy

目的:分析我国服刑人员心理健康水平及影响因素,探讨不同心理健康水平所表现出的前额叶皮层激活差异,为监管部门实施精准治疗及预防伪病现象提供理论依据,为制定心理健康诊断的生物学标准提供案例借鉴。方法:采用横断面研究,纳入129名男性服刑人员,根据SCL-90量表进行心理健康水平测量,使用功能性近红外设备采集前额叶皮层血流动力学反应。结果:人口学因素与心理健康的多项Logistic回归分析发现,疾病史对焦虑组(OR=2.784,95%CI 1.070~7.245,p=0.04)、抑郁组(OR=5.521,95%CI 1.287~23.693,p=0.02)的影响具有统计学意义;年龄对焦虑组(OR=1.496,95%CI 3.334~7.434,p=0.01)、抑郁组(OR=4.548,95%CI 1.103~18.752,p=0.04)的影响具有统计学意义。人口学因素与前额叶皮层激活的t检验发现,疾病史对正常组的眶额叶区(t=-2.167,p=0.03)、抑郁组的眶额叶区(t=-2.575,p=0.01)具有统计学意义;年龄对抑郁组的左背外侧前额区(t=2.196,p=0.03)、精神病组的左颞叶区(t=-2.541,p=0.02)、左背外侧前额区(t=-4.072,p=0.00)、右背外侧前额区(t=-2.343,p=0.03)具有统计学意义。结论:服刑人员的年龄增长、基础疾病增多、体力活动不足以及身体功能和生理机能的减退,导致心理健康水平发生动态变化,甚至诱发心理疾病,成为影响前额叶皮层激活的重要因素。

Through analysis of the mental health level and influencing factors of the Chinese prison inmates and exploring the differences in prefrontal cortex activation exhibited by different mental health levels,a theoretical basis for the implementation of precise treatment and the prevention of pseudo morbid phenomena by the supervisory authorities,and a case study for the development of biological standards for the diagnosis and typing of mental health was provided.A cross-sectional study was used to include 129 male prison inmates,whose mental health level were measured according to the SCL-90 scale.Their frontal cortex hemodynamic responses were collected using a functional near-infrared device.It was shown that multinomial logistic regression analysis of demographic factors and mental health had statistically significant effects of disease history on the anxiety group(OR=2.784,95% CI 1.070-7.245,p=0.04),and on the depression group(OR=5.521,95%CI 1.287-23.693,p=0.02),and age on the anxiety group(OR=1.496,95%CI 3.334-7.434,p=0.01),and a statistically significant effect of age on the depression group(OR=4.548,95%CI 1.103-18.752,p=0.04).A t test of demographic factors and prefrontal cortex activation showed that disease history had a statistically significant effect on orbital frontal regions in the normal group(t=-2.167,p=0.03) and on orbital frontal regions in the depressed group(t=-2.575,p=0.01).Age had a statistically significant effect on left dorsolateral prefrontal regions in the depressed group(t=2.196,p=0.03) and on left temporal lobe regions in the psychotic group(t=-2.541,p=0.02),left dorsolateral prefrontal region(t=-4.072,p=0.00),and right dorsolateral prefrontal region(t=-2.343,p=0.03).It could be concluded that with the ageing of the inmates,the increase in the number of underlying diseases,the lack of physical activity,as well as the decline in physical and physiological functions,which led to dynamic changes in the level of mental health and even induced psychological disorders,became an important factor affecting the activation of the prefrontal cortex.