司库奇尤单抗治疗银屑病的临床疗效

Clinical efficacy of secukinumab in the treatment of psoriasis

目的观察司库奇尤单抗治疗银屑病的临床疗效,评价银屑病患者心理状态的变化。方法选取我院就诊的中重度银屑病患者为研究对象,用随机数字表法分为对照组和观察组各75例。对照组给予卡泊三醇软膏,观察组应用司库奇尤单抗治疗分别在第0、1、2、3、4周进行皮下注射给药,剂量为每次300mg,随后维持该剂量每4周给药一次,均治疗8周。治疗前后分别对患者疾病严重程度(PASI评分)及心理状态(HAMA评分,HAMD评分)进行评价,并使用皮肤镜观察皮损处血管的变化。结果观察组临床总有效率98.67%(74/75)明显高于对照组81.33%(61/75)(χ^(2)=12.43,P<0.05);治疗8周后观察组HAMA评分、HAMD评分降低且低于对照组(P<0.05);银屑病皮损处血管数量减少,血管球直径减小,观察组血管变化较对照组明显(P<0.05)。结论司库奇尤单抗治疗中重度斑块状银屑病疗效显著,且见效快,无明显不良反应,有助于缓解患者的焦虑、抑郁状态。皮肤镜下血管表现具有显著变化,可用于治疗过程中的随访,指导治疗。

Objective To observe the clinical efficacy of skunkizumab in the treatment of psoriasis,evaluate the changes of psychological state of patients with psoriasis.Methods Patients with moderate and severe psoriasis in our hospital were selected as the research object and randomly divided into control group and observation group with 75 cases in each group.The control group was given calcipotriol ointment,and the observation group was given skukiyuzumab by subcutaneous injection at the 0 th,1 st,2 nd,3 rd and 4 th weeks,with a dose of 300mg each time,and then the dose was maintained once every 4 weeks,all patients were treated for 8 weeks.Before and after treatment,the patients'disease severity(PASI score)and mental state(HAMA score,HAMD score)were evaluated,and the changes of blood vessels in the lesions were observed by dermatoscope.Results The total clinical effective rate of the group using skukiyuzumab 98.67%(74/75)was significantly higher than that of the control group 81.33%(61/75)(χ^(2)=12.43,P<0.05);After 8 weeks of treatment,the scores of Hama and Hamd in the observation group were significantly lower than those in the control group(P<0.05);and the number of vessels and the diameter of vessels in psoriatic lesions were decreased,and the changes of vessels in the observation group were more obvious than those in the control group(P<0.05).Conclusion Secukinumab has significant curative effect in the treatment of moderate to severe plaque psoriasis,and the effect is fast,without obvious adverse reactions,and can significantly improve the anxiety and depression state of patients.There are significant changes in vascular manifestation under dermoscopy,it can be used to follow-up during treatment and guide treatment.