宫腔灌注治疗反复种植失败的研究进展

Research progress on intrauterine infusion therapy for recurrent implant failure

人类辅助生殖技术的快速发展提高了不孕不育夫妇的临床妊娠率,但是对于反复种植失败病患的妊娠率依旧较低。反复种植失败给病患的身体、精神、经济带来多重压力,其病因复杂,包括母体因素、胚胎因素、男性因素,其中最重要的是母体因素中的子宫内膜因素。近年来改善反复种植失败病患的子宫内膜容受性进而促进良好的妊娠结局成为生殖热点。宫腔灌注是有效改善子宫内膜容受性的一种治疗方法,只是目前尚处于临床研究阶段。本文将综述分析宫腔灌注对反复种植失败患者妊娠结局的影响,以期为临床医师提供更加广泛的诊疗思路。

The rapid development of human assisted reproductive technology has improved the clinical pregnancy rate of infertile couples,but the pregnancy rate of patients with repeated implantation failure still remains low.Repeated implantation failure brings multiple pressures to patients'bodies,spirits and finances.Its'etiology is complicated,including maternal factors,embryonic factors and male factors,among which the most important is the endometrial factor.In recent years,improving endometrial receptivity of patients with repeated implantation failure and promoting good pregnancy outcome has become a reproductive hotspot.Uterine perfusion is an effective treatment method to improve endometrial receptivity,but it is still in the clinical research stage.Based on a large number of relevant data,this paper will review and analyze the progress of intrauterine perfusion on pregnancy outcome of repeated implantation failure,in order to provide clinicians with more extensive diagnosis and treatment ideas.