系统性红斑狼疮继发性干燥综合征抗SSB抗体阳性儿童临床特点

Clinical characteristics of anti SSB antibody positive children with Sjogren’s syndrome secondary to systemic lupus erythematosus

目的探讨系统性红斑狼疮继发性干燥综合征中抗干燥综合征B(SSB)抗体阳性儿童临床特点。方法回顾性分析2015年1月至2018年12月该院收治的65例系统性红斑狼疮继发性干燥综合征儿童临床资料,根据抗SSB抗体结果分为阳性组(34例)和阴性组(31例),分析比较两组临床特点。结果阳性组容易发生复发性腮腺肿大、类风湿因子(RF)及抗RO52抗体阳性。阳性组免疫球蛋白G(IgG)、红细胞沉降率(ESR)增高程度均明显高于阴性组,差异均有统计学意义(P<0.05)。结论系统性红斑狼疮患儿中出现复发性腮腺肿大、RF阳性、高水平IgG时,尽早监测抗SSB抗体。系统性红斑狼疮继发性干燥综合征中抗SSB抗体阳性的儿童应加强定期随诊,警惕恶性肿瘤的发生。

Objective To explore the clinical characteristics of children with Sjogren’s syndrome B(SSB)antibody positive in secondary Sjogren’s syndrome of systemic lupus erythematosus.Methods The clinical data of 65 children with secondary Sjogren’s syndrome with systemic lupus erythematosus admitted to this hospital from January 2015 to December 2018 were retrospectively analyzed and divided into a positive group(34 cases)and a negative group(31 cases)according to the results of anti-SSB antibodies,and the clinical characteristics of the two groups were analyzed and compared.Results The observation group was prone to recurrent parotid gland enlargement,rheumatoid factor(RF)positive and anti-RO52 antibody positive.The levels of immunoglobulin G(IgG)and erythrocyte sedimentation rate(ESR)in the observation group were significantly higher than those in the control group,and the difference was statistically significant(P<0.05).Conclusion When recurrent parotid gland enlargement,RF positive and high level of IgG occur in children with systemic lupus erythematosus,anti-SSB antibody should be monitored as soon as possible.Children with SSB antibody positive in Sjogren’s syndrome secondary to systemic lupus erythematosus should strengthen regular follow-up and be alert to the occurrence of malignant tumors.