栀子甘草豉汤加味治疗联合雷贝拉唑对痰热郁阻型反流性食管炎患者中医证候及食管动力学的影响

Effect of Modified Zhizi Gancao Fermented Soya Bean DecoctionCombined with Rabeprazole on Traditional Chinese MedicineSyndrome and Esophageal Dynamics in Patients withPhlegm Heat Stagnation Type Reflux Esophagitis

目的:探讨栀子甘草豉汤加味治疗联合雷贝拉唑在痰热郁阻型反流性食管炎(RE)中的临床效果。方法:共66例RE患者,均为2020年1月—2023年8月我院收治,按随机数字表法分为2组(各33例)。对照组采用雷贝拉唑治疗,观察组加用栀子甘草豉汤加味治疗,持续8周。比较两组临床疗效、中医证候积分、胃肠激素水平、食管动力学、不良反应。结果:观察组总有效率较对照组高,治疗后中医证候积分较对照组低(P<0.05);观察组治疗后GAS、MOT水平较对照组高(P<0.05);观察组治疗后食管动力学优于对照组(P<0.05);两组不良反应相比无差异(P>0.05)。结论:栀子甘草豉汤加味治疗联合雷贝拉唑可提高RE治疗效果,加快食管动力学复常,促进疾病症状消失,纠正胃肠激素紊乱,安全可靠。

Objective:To explore the clinical effect of modified Zhizi Gancao FERMENTED SOYA BEAN Decoction combined with rabeprazole in the treatment of phlegm heat stagnation type reflux esophagitis(RE).Methods:A total of 66 RE patients were admitted to our hospital from January 2020 to August 2023.They were randomly divided into two groups(33 cases each)using a random number table method.The control group received treatment with rabeprazole,while the observation group received treatment with modified Zhizi Gancao Fermented Soya Bean Decoction for 8 weeks.Compare the clinical efficacy,traditional Chinese medicine syndrome score,gastrointestinal hormone levels,esophageal dynamics,and adverse reactions between two groups.Results:The total effective rate of the observation group was higher than that of the control group,and the TCM syndrome score after treatment was lower than that of the control group(P<0.05);The levels of GAS and MOT in the observation group were higher than those in the control group after treatment(P<0.05);The esophageal dynamics in the observation group were better than those in the control group after treatment(P<0.05);There was no difference in adverse reactions between the two groups(P>0.05).Conclusion:The combination of Zhizi Gancao Fermented Soya Bean Decoction and rabeprazole can improve the therapeutic effect of RE,accelerate the normalization of esophageal dynamics,promote the disappearance of disease symptoms,correct gastrointestinal hormone disorders,and is safe and reliable.