肺癌组织中MTA1、VEGF-C表达水平与患者临床分期及预后的相关性

Expression of MTA1 and VEGF-C in Lung Cancer Tissue and Correlation with Clinical Staging and Prognosis of Patients

【目的】探讨肺癌组织中转移相关基因1(MTA1)、血管内皮生长因子C(VEGF-C)表达水平及其与患者临床分期及预后的相关性。【方法】回顾分析本院收治的85例肺癌患者的临床资料,收集患者的肺癌组织及癌旁组织,采用免疫组化法检测MTA1、VEGF-C阳性表达情况,采用PCR荧光定量法检测MTA1、VEGF-C表达水平,比较不同临床病理参数、预后结局患者的MTA1、VEGF-C阳性表达率。【结果】肺癌组织MTA1、VEGF-C阳性表达率及两者表达水平均高于癌旁组织,差异有统计学意义(P<0.05)。不同TNM分期、肿瘤直径及分化、淋巴结转移、脉管侵犯、预后情况患者的MTA1、VEGF-C阳性表达率及表达水平比较,差异均有统计学意义(P<0.05)。MTA1及VEGF-C阳性表达患者24个月累积无进展生存率分别低于两者阴性表达患者,差异有统计学意义(P<0.05)。肺癌组织中MTA1、VEGF-C表达水平与肿瘤TNM分期、肿瘤直径、淋巴结转移、脉管侵犯、预后结局均呈正相关(P<0.05),与分化程度呈负相关(P<0.05)。【结论】MTA1、VEGF-C在肺癌组织内多呈阳性表达,其表达水平与肿瘤病理分期、肿瘤直径、预后等密切相关。

【Objective】To analyze the expression levels of metastasis related gene 1(MTA1)and vascular endothelial growth factor C(VEGF-C)in lung cancer tissue and their correlation with clinical staging and prognosis of patients.【Methods】Retrospective analysis of clinical data from 85 patients diagnosed with lung cancer in our hospital.All lung cancer tissues and adjacent tissues of the patients were collected as pathological specimens,and the positive expression rates of MTA1 and VEGF-C were detected using immunohistochemistry.Meanwhile,the expression levels of MTA1 and VEGF-C was detected by PCR fluorescence quantification method.The positive expression rates of MTA1 and VEGF-C were compared among patients with different clinical pathological parameters and prognostic outcomes.【Results】The positive rates of MTA1 and VEGF-C in lung cancer tissues were higher than those in adjacent tissues(P<0.05).And the expression levels of both proteins of cancer tissues were also higher than those of the adjacent tissues(P<0.05).The positive rates and expression levels of MTA1 and VEGF-C in patients with TNM stages,low differentiation,tumor diameter>5 cm,lymph node metastasis,vascular invasion,and poor prognosis showed an upward trend(P<0.05).The cumulative progression free survival rate at 24 months in the MTA1 positive expression group was lower than the negative expression group(P<0.05).The survival rate of the VEGF-C positive expression group was lower than the negative expression group,and the difference was significant(P<0.05).The expression of MTA1 and VEGF-C in lung cancer tissue is closely related to tumor TNM staging,differentiation degree,tumor diameter,lymph node metastasis,vascular invasion,and prognosis(P<0.05).【Conclusion】MTA1 and VEGF-C are often positively expressed in lung cancer tissues,and their expression levels can serve as important factors for evaluating pathological features such as tumor staging,diameter,and prognosis to a certain extent.It is worth further exploration in clinical practice.