纤维蛋白原及D-二聚体水平与脑梗死患者认知功能障碍的相关性

Relationship of Fibrinogen and D-Dimer Levels with Cognitive Dysfunction in Patients with Cerebral Infarction

【目的】探讨血清中纤维蛋白原(FIB)及D-二聚体(D-D)水平与脑梗死患者认知功能障碍的关系。【方法】脑梗死患者82例,根据其认知功能障碍程度分为轻度组、中度组、重度组,选择同期30例健康体检者为对照组。比较所有对象的血清FIB及D-D水平,并进行认知功能评估;采用Pearson分析FIB及D-D水平与认知功能障碍程度的相关性;使用Spearman分析FIB及D-D与蒙特利尔认知量表(MoCA)评分的相关性。【结果】与对照组相比,轻度组、中度组、重度组的FIB及D-D水平均显著升高(P<0.05);重度组的FIB及D-D水平高于轻度组和中度组(P<0.05);FIB及D-D水平与脑梗死患者的认知功能障碍程度呈正相关(均P<0.05);FIB及D-D水平与认知功能存在线性关系(R 2=0.531、0.478)。【结论】脑梗死患者的认知功能障碍程度与血清中的FIB及D-D水平呈正相关,可作为脑梗死患者认知功能障碍程度的独立预测指标。

【Objective】To investigate the relationship between serum fibrinogen(FIB)and D-dimer(D-D)levels and cognitive dysfunction in patients with cerebral infarction.【Methods】Eighty-two patients with cerebral infarction were divided into mild,moderate,and severe groups according to the degree of cognitive dysfunction.Additionally,30 healthy individuals undergoing physical examination during the same period were selected as the control group.Serum FDP and D-D levels were compared among all groups,and cognitive function was assessed as well.Pearson analysis was used to evaluate the correlation between FIB and D-D levels and the degree of cognitive dysfunction.Spearman analysis was performed to determine the correlation of MoCA scores with FIB and D-D levels.【Results】Compared to the control group,FIB and D-D levels were significantly higher in the mild,moderate,and severe groups(P<0.05).FIB and D-D levels in the severe group were higher than those in the mild and moderate groups(P<0.05).Levels of FIB and D-D were positively correlated with the degree of cognitive dysfunction in patients with cerebral infarction(both P<0.05).There was a linear relationship between FIB and D-D levels and cognitive function(R 2=0.531 and 0.478,respectively).【Conclusion】The degree of cognitive dysfunction in patients with cerebral infarction is positively correlated with both serum FIB and D-D levels,which can be served as independent predictors of the severity of cognitive dysfunction in these patients.