卡孕栓联合垂体后叶素在剖宫产术中出血患者中的应用效果

Application effect of carboplatin suppository combined with pituitrin in patients with intraoperative hemorrhage during cesarean section

目的研究卡前列甲酯栓(商品名:卡孕栓)联合垂体后叶素在剖宫产术中出血患者中的应用效果。方法择取68例剖宫产术中出血患者,通过随机数字表法分为对照组与观察组,每组34例。对照组常规应用缩宫素治疗,观察组在应用缩宫素的基础上接受垂体后叶素+卡孕栓治疗。对比两组术中、术后出血情况,术后相关指标,血液相关指标,血压水平,产后出血率与不良反应发生情况。结果观察组的术中及术后1~2 h、2~24 h的出血量分别为(923.05±100.83)、(154.67±22.06)、(55.60±6.74)ml,相较于对照组的(1089.54±176.96)、(243.52±37.91)、(101.46±10.32)ml均更少(P<0.05)。观察组的输血量(467.80±42.63)ml同对照组的(544.96±54.71)ml相比显著更少,且宫缩持续时间(2.05±0.19)d、肛门排气恢复时间(29.64±4.53)h、住院时间(5.28±0.45)d、产后恶露持续时间(22.12±3.36)d均比对照组的(2.86±0.33)d、(38.22±6.07)h、(8.75±0.69)d、(30.70±4.59)d更短(P<0.05)。术后,两组患者的血红蛋白(Hb)、红细胞压积(HCT)水平均较术前降低,但同对照组的(104.25±5.6)g/L、(0.29±0.02)相比,观察组的Hb(114.59±7.23)g/L、HCT(0.36±0.03)均更高(P<0.05)。术后,两组的舒张压、收缩压均较术前升高(P<0.05),但观察组的舒张压(85.96±5.08)mm Hg(1 mm Hg=0.133 kPa)、收缩压(134.01±8.29)mm Hg均较对照组的(89.84±6.57)、(137.75±11.85)mm Hg更低(P<0.05)。对照组的产后出血率17.65%较观察组的2.94%更高(P<0.05);两组不良反应发生率对比无显著差异(P>0.05)。结论对剖宫产术中出血患者实施卡孕栓联合垂体后叶素治疗具有较好的效果。

Objective To study the application effect of carboplatin suppository combined with pituitrin in patients with intraoperative hemorrhage during cesarean section.Methods 68 patients with intraoperative hemorrhage during cesarean section were selected.The patients were divided into a control group and an observation group using a random number table method,each with 34 patients.The control group was treated with conventional treatment of oxytocin,while the observation group was treated with pituitrin and carboplatin suppositories on the basis of oxytocin.The intraoperative and postoperative bleeding,postoperative related indexes,blood related indexes,blood pressure level,postpartum hemorrhage rate and adverse reactions were compared between the two groups.Results The amount of bleeding in the observation group were(923.05±100.83),(154.67±22.06)and(55.60±6.74)ml intraoperatively,1-2 h postoperatively and 2-24 h postoperatively,which were less than(1089.54±176.96),(243.52±37.91)and(101.46±10.32)ml in the control group(P<0.05).The observation group had significantly lower blood transfusion volume of(467.80±42.63)ml than(544.96±54.71)ml in the control group;in the observation group,the duration of uterine contractions was(2.05±0.19)d,the recovery time of anal exhaust was(29.64±4.53)h,the hospitalization time was(5.28±0.45)d,and the duration of postpartum lochia was(22.12±3.36)d,which were shorter than(2.86±0.33)d,(38.22±6.07)h,(8.75±0.69)d,and(30.70±4.59)d in the control group(P<0.05).Postoperatively,the levels of hemoglobin(Hb)and hematocrit(HCT)in both groups were lower than those preoperatively;the observation group had Hb of(114.59±7.23)g/L and HCT of(0.36±0.03),which were higher than(104.25±5.6)g/L and(0.29±0.02)in the control group(P<0.05).Postoperatively,the diastolic blood pressure and systolic blood pressure in both groups were higher than those preoperatively(P<0.05).The observation group had diastolic blood pressure of(85.96±5.08)mm Hg(1 mm Hg=0.133 kPa)and systolic blood pressure of(134.01±8.29)mm Hg,which were lower than(89.84±6.57)and(137.75±11.85)mm Hg in the control group(P<0.05).The rate of postpartum hemorrhage in the control group was 17.65%,which was higher than 2.94%in the observation group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of carboplatin and pituitrin has a good effect on patients with intraoperative hemorrhage during cesarean section.