阿立哌唑联合碳酸锂治疗双相情感障碍躁狂发作的效果及对患者生活质量的影响探讨

The effect of aripiprazole combined with lithium carbonate in the treatment of manic episode of bipolar disorder and its influence on quality of life of patients

目的研究双相情感障碍躁狂发作患者选择阿立哌唑和碳酸锂联合治疗的效果及对其生活质量的影响。方法132例双相情感障碍躁狂发作患者,以随机数字表法分为参照组(n=66,碳酸锂治疗)和实验组(n=66,阿立哌唑联合碳酸锂治疗)。对比两组患者疗效及治疗前后生活质量、躁狂状态与炎症水平。结果治疗前两组生理健康、社会关系、心理健康、周围环境评分对比差异无统计学意义(P>0.05);治疗后实验组生理健康、社会关系、心理健康、周围环境评分分别为(81.36±4.21)、(82.47±3.97)、(83.08±4.47)、(85.35±2.79)分,明显优于参照组的(75.27±3.99)、(76.78±3.90)、(77.17±4.23)、(80.46±2.67)分(P<0.05)。治疗前两组贝克-拉范森躁狂量表(BRMS)评分及肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)水平对比差异无统计学意义(P>0.05);治疗后实验组BRMS评分(16.16±1.42)分、TNF-α(120.77±13.48)ng/L和IL-6(32.66±4.13)pg/ml均明显低于参照组的(20.01±1.68)分、(137.82±16.07)ng/L、(38.15±4.40)pg/ml(P<0.05)。实验组总有效率95.45%明显优于参照组的78.79%(P<0.05)。结论双相情感障碍躁狂发作患者选择阿立哌唑和碳酸锂联合治疗效果更加理想,更有益于患者躁狂状态、生活质量及炎症水平的改善,值得推广。

Objective To study the effect of aripiprazole combined with lithium carbonate in the treatment of manic episode of bipolar disorder and its influence on quality of life of patients.Methods A total of 132 patients with manic episodes of bipolar disorder were divided into a reference group(n=66,treated with lithium carbonate)and an experimental group(n=66,treated with aripiprazole and lithium carbonate)by random number table method.The efficacy,quality of life,manic state and inflammation level before and after treatment were compared between the two groups.Results Before treatment,there was no significant difference in the scores of physical health,social relations,mental health and surrounding environment between the two groups(P>0.05).After treatment,the scores of physical health,social relations,mental health and surrounding environment of the experimental group were(81.36±4.21),(82.47±3.97),(83.08±4.47)and(85.35±2.79)points,which were significantly better than(75.27±3.99),(76.78±3.90),(77.17±4.23)and(80.46±2.67)points of the reference group(P<0.05).Before treatment,there were no significant differences in the scores of the Baker-Raphson Mania Scale(BRMS)and the levels of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)between the two groups(P>0.05).After treatment,the experimental group had BRMS score of(16.16±1.42)points,TNF-αof(120.77±13.48)ng/L and IL-6 of(32.66±4.13)pg/ml,which were significantly lower than(20.01±1.68)points,(137.82±16.07)ng/L and(38.15±4.40)pg/ml in the reference group(P<0.05).The total effective rate was 95.45%in the experimental group,which was significantly higher than 78.79%in the reference group(P<0.05).Conclusion The combined treatment of aripiprazole and lithium carbonate in patients with manic episode of bipolar disorder is more ideal,which is more beneficial to the improvement of manic state,quality of life and inflammation level of patients,and is worth promoting.