双侧星状神经节阻滞联合穴位注射治疗过敏性鼻炎的效果观察

Observation on the effect of bilateral stellate ganglion block combined with acupoint injection in the treatment of allergic rhinitis

目的观察过敏性鼻炎患者实施双侧星状神经节阻滞(SGB)联合穴位注射治疗的效果。方法600例过敏性鼻炎患者,以随机性为分组原则分为对照组(300例)、观察组(300例)。对照组实施双侧SGB治疗,观察组在对照组基础上实时穴位注射治疗。比较两组的治疗效果、不良事件发生情况、免疫指标[免疫球蛋白E(IgE)]与炎性因子[白细胞介素-4(IL-4)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、白三烯B4(LTB4)]水平、临床症状积分。结果观察组治疗总有效率98.33%高于对照组的78.33%(P<0.05)。两组不良事件发生率比较差异较小(P>0.05)。治疗后,观察组IgE(45.38±4.77)IU/ml、IL-4(18.82±1.20)pg/ml、IL-6(16.55±1.72)pg/ml、IL-10(13.55±1.08)pg/ml、LTB4(53.58±5.77)ng/L均低于对照组的(77.82±7.11)IU/ml、(25.77±2.55)pg/ml、(26.55±2.58)pg/ml、(19.91±1.25)pg/ml、(72.58±7.72)ng/L(P<0.05)。治疗前,两组喷嚏、流涕、鼻塞、鼻痒积分比较差异较小(P>0.05);治疗后,观察组喷嚏、流涕、鼻塞、鼻痒积分分别为(0.53±0.10)、(0.48±0.20)、(0.45±0.10)、(0.40±0.05)分,均低于对照组的(0.98±0.12)、(0.81±0.13)、(0.88±0.20)、(0.89±0.12)分(P<0.05)。结论对过敏性鼻炎患者实施双侧SGB联合穴位注射治疗,疗效和安全性均较高。

Objective To observe the effect of bilateral stellate ganglion block(SGB)combined with acupoint injection in the treatment of allergic rhinitis.Methods 600 patients with allergic rhinitis were randomly divided into a control group(300 cases)and an observation group(300 cases).The control group received bilateral SGB treatment,and the observation group received real-time acupoint injection treatment on the basis of the control group.Both groups were compared in terms of therapeutic effect,occurrence of adverse events,levels of immune indicators[immunoglobulin E(IgE)]and inflammatory factors[interleukin-4(IL-4),interleukin-6(IL-6),interleukin-10(IL-10),leukotriene B4(LTB4)]and clinical symptom scores.Results The total effective rate of the observation group was 98.33%,which was higher than 78.33%of the control group(P<0.05).There was little difference in the incidence of adverse events between the two groups(P>0.05).After treatment,the observation group had IgE of(45.38±4.77)IU/ml,IL-4 of(18.82±1.20)pg/ml,IL-6 of(16.55±1.72)pg/ml,IL-10 of(13.55±1.08)pg/ml,and LTB4 of(53.58±5.77)ng/L,which were lower than(77.82±7.11)IU/ml,(25.77±2.55)pg/ml,(26.55±2.58)pg/ml,(19.91±1.25)pg/ml,and(72.58±7.72)ng/L of the control group(P<0.05).Before treatment,the difference in scores of sneezing,runny nose,stuffy nose and itchy nose between the two groups were relatively small(P>0.05).After treatment,the scores of sneezing,runny nose,stuffy nose and itchy nose in the observation group were(0.53±0.10),(0.48±0.20),(0.45±0.10)and(0.40±0.05)points,which were lower than(0.98±0.12),(0.81±0.13),(0.88±0.20)and(0.89±0.12)points in the control group(P<0.05).Conclusion Implementing bilateral SGB combined with acupoint injection therapy for patients with allergic rhinitis has high efficacy and safety.