湿润烧伤膏联合银离子敷料治疗压疮的临床疗效分析

Clinical efficacy analysis of moist exposed burn ointment combined with silver ion dressing in treatment of pressure ulcer

目的分析湿润烧伤膏联合银离子敷料治疗压疮的临床疗效。方法100例压疮患者,依据入院时间不同分成对照组(应用银离子敷料治疗,50例)和观察组(应用湿润烧伤膏联合银离子敷料治疗,50例)。对比两组患者炎性因子[白介素-8(IL-8)、白介素-6(IL-6)、超敏C反应蛋白(hs-CRP)和肿瘤坏死因子-α(TNF-α)]水平,焦虑评分、抑郁评分、视觉模拟评分法(VAS)评分,临床疗效,瘢痕增生程度,生活质量评分。结果治疗后,两组的IL-8、IL-6、hs-CRP、TNF-α水平较治疗前明显降低,且观察组的IL-8(31.19±2.92)pg/ml、IL-6(18.84±1.67)pg/ml、hs-CRP(7.52±0.73)mg/L、TNF-α(14.22±1.24)ng/ml明显低于对照组的(44.68±4.27)pg/ml、(27.21±2.52)pg/ml、(13.65±1.17)mg/L、(21.16±1.92)ng/ml(P<0.05)。治疗后,两组的焦虑评分、抑郁评分、VAS评分较治疗前均明显降低,且观察组的焦虑评分(36.22±3.41)分、抑郁评分(38.84±3.67)分、VAS评分(2.25±0.21)分均显著低于对照组的(42.53±4.04)、(44.75±4.28)、(4.18±0.39)分(P<0.05)。观察组患者的治疗总有效率(98.00%)显著高于对照组(84.00%)(P<0.05)。观察组患者的扁平瘢痕率为92.00%、瘢痕增生率为8.00%,与对照组的扁平瘢痕率(38.00%)和瘢痕增生率(62.00%)对比有差异(P<0.05)。观察组治疗后的生理功能评分为(86.24±6.36)分、躯体疼痛评分为(87.15±6.42)分、精力评分为(88.38±6.49)分、社会功能评分为(86.76±6.41)分,均显著高于对照组的(77.93±5.82)、(79.38±5.91)、(81.02±5.98)、(78.25±5.88)分(P<0.05)。结论压疮患者使用湿润烧伤膏联合银离子敷料治疗,可以有效减轻疼痛,降低炎性因子水平,且患者的瘢痕增生发生率较低,能够有效提升患者的生活质量,临床治疗效果较好。

Objective To analyze the clinical efficacy of moist exposed burn ointment combined with silver ion dressing in treatment of pressure ulcer.Methods According to the time of admission,100 patients with pressure ulcer were divided into a control group(50 cases,treated with silver ion dressing)and an observation group(50 cases,treated with moist exposed burn ointment and silver ion dressing).Patients in both groups were compared in terms of levels of inflammatory factors[interleukin-8(IL-8),interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)],anxiety score,depression score,visual analog scale(VAS)score,clinical efficacy,scar hyperplasia degree,and quality of life score.Results After treatment,the levels of IL-8,IL-6,hs-CRP and TNF-αin both groups were significantly decreased compared with those before treatment;the observation group had IL-8 of(31.19±2.92)pg/ml,IL-6 of(18.84±1.67)pg/ml,hs-CRP of(7.52±0.73)mg/L and TNF-αof(14.22±1.24)ng/ml,which were significantly lower than(44.68±4.27)pg/ml,(27.21±2.52)pg/ml,(13.65±1.17)mg/L and(21.16±1.92)ng/ml in the control group(P<0.05).After treatment,the anxiety score,depression score and VAS score in both groups were significantly lower than those before treatment;the observation group had anxiety score of(36.22±3.41)points,depression score of(38.84±3.67)points and VAS score of(2.25±0.21)points,which were significantly lower than(42.53±4.04),(44.75±4.28)and(4.18±0.39)points in the control group(P<0.05).The total effective rate of the observation group(98.00%)was significantly higher than that of the control group(84.00%)(P<0.05).The flat scar rate and scar hyperplasia rate of the observation group were 92.00%and 8.00%,which were significantly different from 38.00%and 62.00%of the control group(P<0.05).After treatment,the scores of physiologic function,bodily pain,energy and social function were(86.24±6.36),(87.15±6.42),(88.38±6.49)and(86.76±6.41)points in the observation group,which were significantly higher than(77.93±5.82),(79.38±5.91),(81.02±5.98)and(78.25±5.88)points in the control group(P<0.05).Conclusion Moist exposed burn ointment combined with silver ion dressing for pressure ulcer patients can effectively relieve pain and reduce the level of inflammatory factors,and the incidence of scar hyperplasia in patients is low,which can effectively improve the quality of life of patients,and the clinical treatment effect is good.