光聚合3D打印在药物递送领域的前沿、机遇与挑战

Frontier,Opportunities and Challenges of Vat Photopolymerization 3D Printing Technology in Drug Delivery

药物递送系统的革新对于优化药效和减小毒副作用至关重要。近年来,个性化递送系统因其能够精准定制药物递送方案,满足患者个性化需求而受到越来越多的关注。3D打印技术,特别是光聚合3D打印技术,为具有复杂结构的药物载体和递送装置的制造提供了新途径。基于该技术制备的药物递送系统,可精确控制药物释放,且支持功能性递送,从而实现个性化治疗。以微针贴片和腔内支架为例,重点介绍了光聚合3D打印技术在药物递送装置和个性化释药医疗器械领域的研究进展,并探讨这一技术面临的机遇与挑战。

Innovations in drug delivery systems are crucial for optimizing therapeutic effectiveness and reducing adverse effects.In recent years,personalized delivery systems have attracted more and more attention due to their ability to customize drug delivery schemes accurately to meet the individualized needs of patients.3D printing technology,especially vat photopolymerization 3D printing technology,provides new ways for the manufacture of drug carriers and delivery devices with complex structures.The drug delivery systems prepared based on this technology can precisely control drug release and support functional delivery,thereby achieving personalized treatment.Taking microneedle patches and endoluminal stents as examples,this article focuses on the research progress of vat photopolymerization 3D printing technology in drug delivery devices and personalized drug release medical devices,and discusses the opportunities and challenges of this technology.