药物递送技术的研究进展

Advances in Research on Drug Delivery Technology

药物递送被认为是药物开发的“最后一公里”。自1952年作为标志性产品的Dexedrine®Spansule®缓释胶囊获批上市至今,药物递送技术已走过了70余年的发展历程,并在赋能传统化药以及蛋白质、多肽和单抗等生物药物的开发方面取得了显著的进步。以智能药物递送系统、微/纳米机器人、仿生递送系统等前沿领域为例,综述了药物递送技术的最新研究进展。

Drug delivery is considered the“last kilometer”of drug development.Since the breakthrough product Dexedrine®Spansule®sustained-release capsule was approved in 1952,drug delivery technology has evolved over 70 years and has made remarkable advances in enabling the development of traditional chemical drugs as well as biologic drugs such as proteins,peptides and monoclonal antibodies.Recent research progress in drug delivery technologies are reviewed with examples from frontier fields such as intelligent drug delivery systems,micro/nano robots,and biomimetic delivery systems.