替格瑞洛联合阿司匹林对冠心病心绞痛患者心功能指标和血清Hcy、NT-proBNP水平的影响

Effects of ticagrelor combined with aspirin on cardiac function indexes,serum Hcy and NT-proBNP in patients with angina pectoris of coronary heart disease

目的探究替格瑞洛联合阿司匹林对冠心病心绞痛患者心功能指标和血清Hcy、NT-proBNP水平的影响。方法选取2021年1月—2022年12月在蚌埠市第一人民医院就诊的152例冠心病心绞痛患者,随机分为观察组和对照组,每组76例。对照组在常规治疗基础上给予阿司匹林治疗,观察组在此基础上联合替格瑞洛治疗。观察两组治疗后的疗效,治疗前后的心绞痛发作情况、心功能指标[左室射血分数(LVEF)、每搏量(SV)和心输出量(CO)]、血脂指标[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)]、血清同型半胱氨酸(Hcy)和氨基末端脑钠肽前体(NT-proBNP)水平以及治疗期间不良反应发生情况。结果治疗后,观察组治疗总有效率高于对照组(P<0.05);观察组心绞痛持续时间短于对照组,心绞痛发作频率低于对照组(P<0.05);观察组LVEF、SV和CO水平均明显高于对照组(P<0.05);观察组血脂指标变化显著优于对照组(P<0.05);观察组Hcy和NT-proBNP水平明显低于对照组(P<0.05);治疗期间,两组不良反应发生率比较差异无统计学意义(P>0.05)。结论使用替格瑞洛联合阿司匹林治疗冠心病心绞痛患者有良好疗效,能减轻临床症状,对患者心功能有明显改善,其能降低血脂指标和血清Hcy、NT-proBNP水平,不增加不良反应发生率,安全性良好。

Objective To explore the effects of ticagrelor combined with aspirin on cardiac function indexes,serum homocysteine(Hcy)and N-terminal pro-B-type natriuretic peptide(NT-proBNP)in patients with angina pectoris of coronary heart disease.Methods A total of 152 patients with angina pectoris of coronary heart disease treated in the hospital were enrolled and randomly divided into experimental group and control group from January 2021 to December 2022,76 cases in each group.On basis of routine treatment,control group was treated with aspirin,while experimental group was treated with ticagrelor on basis of control group.The curative effect after treatment,angina attacks,cardiac function indexes[left ventricular ejection fraction(LVEF)],stroke volume(SV),cardiac output(CO),blood lipid indexes[total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)],serum Hcy and NT-proBNP before and after treatment,and the incidence of adverse reactions during treatment in the two groups were observed.Results After treatment,total response rate of treatment in experimental group was higher than that in control group(P<0.05).The duration of angina pectoris in the experimental group was shorter than that in the control group,and the frequency of angina pectoris attack was lower than that in the control group(P<0.05).The levels of LVEF,SV and CO in experimental group were significantly higher than those in control group(P<0.05).The change of blood lipid indexes in the experimental group was significantly better than that in the control group(P<0.05).The levels of Hcy and NT-proBNP in experimental group were significantly lower than those in control group(P<0.05).During treatment,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The curative effect of ticagrelor combined with aspirin is good on patients with angina pectoris of coronary heart disease,which can reduce clinical symptoms,significantly improve cardiac function,reduce levels of blood lipid indexes,serum Hcy and NT-proBNP,and will not increase the incidence of adverse reactions,with good safety.