血液生物标志物在肺栓塞中的诊断和预后价值的研究进展

Research progress on the diagnostic and prognostic value of blood biomarkers for pulmonary embolism

肺栓塞(PE)已成为医院内猝死的重要原因。目前血清D二聚体常在临床中被应用于PE的排除诊断。但由于其受多种因素影响,特异性差,仍需要寻找更多便捷的血液标志物,来提高PE的早期诊断率及协助PE患者危险分层和管理。本文对D二聚体及其他具有代表性的血液生物标志物,包括纤维蛋白原、中性粒细胞/淋巴细胞比率(NLR)、血小板/淋巴细胞比率(PLR)、心脏相关标志物、分子相关标志物与PE的关系的研究进展进行阐述,综述了血液中PE相关生物标志物的临床价值,包括其诊断和预后能力。

Pulmonary embolism(PE)has become an important cause of sudden death in hospital.At present,serum D-dimer is often used in the exclusion diagnosis of PE in clinical practice.However,due to its poor specificity and influence of various factors,more convenient blood markers are still needed to improve the early diagnosis rate of PE and assist in risk stratification and management of PE patients.This article elaborates the research progress of the association of D-dimer and other representative blood biomarkers,including fibrinogen,neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR),heart-related markers,molecular related markers with PE.This paper reviews the clinical value of PE-related biomarkers in blood,including their diagnostic and prognostic abilities.