2型糖尿病人群内脏脂肪面积与甲状腺激素的相关性分析

Study on the correlation between visceral fat area and thyroid hormone in patients with type 2 diabetes

目的:探讨2型糖尿病(T2DM)病人血清甲状腺激素水平与腹部内脏脂肪面积(VFA)的相关性。方法:收集328例T2DM病人,通过测量血清总甲状腺激素、总三碘甲腺原氨酸(TT3)、游离甲状腺素、游离三碘甲腺原氨酸(FT3)、促甲状腺激素和生化指数(空腹血糖、空腹胰岛素、糖化血红蛋白、总胆固醇、三酰甘油、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇),并对VFA和皮下脂肪面积进行生物电阻方法测定。结果:Spearman相关分析表明,TT3、FT3与VFA呈明显正相关关系(r=0.184、0.173,P<0.01)。多元线性回归分析表明,TT3与VFA具有独立的相关关系(P<0.05),TT3每增加1 nmol/L,VFA增加13 cm 2。结论:T2DM病人的TT3与VFA相关,可能是机体对过量的内脏脂肪组织的自我保护机制,是机体保持代谢平衡的适应机制。

Objective:To explore the relationship between thyroid hormone and abdominal visceral fat area(VFA)in patients with type 2 diabetes mellitus(T2DM).Methods:The serum levels of total thyroid hormone,total triiodothyronine(TT3),free thyroxine,free triiodothyronine(FT3)and thyroid stimulating hormone,and biochemical indexes(fasting blood glucose,fasting insulin,glycated hemoglobin,total cholesterol,triglyceride,low density lipoprotein cholesterol and high density lipoprotein cholesterol)in 328 patients with T2DM were measured,and the VFA and subcutaneous fat area were detected by bioelectrical impedance method.Results:The results of Spearman correlation analysis showed that the TT3 and FT3 were positively correlated with VFA(r=0.184,0.173,P<0.01).The results of multiple linear regression analysis showed that there was an independent correlation between TT3 and VFA(P<0.05),and the VFA increased by 13 cm2 for every 1 nmol/L of TT3 increased.Conclusions:The TT3 in T2DM patients is related to VFA,which may be the self-protection mechanism of the body against excess visceral adipose tissue,and adaptive mechanism of the body to maintain metabolic balance.