不同剂量来曲唑联合HMG对多囊卵巢综合征患者促排卵的疗效观察

Observation of the therapeutic effect of different doses of letrozole combined with HMG on ovulation induction in patients with polycystic ovary syndrome

目的探究不同剂量来曲唑联合尿促性腺激素(HMG)对多囊卵巢综合征(PCOS)患者促排卵的疗效。方法选取30例PCOS患者,按照抽签法将其分为对照组(2.5mg来曲唑+HMG治疗)和研究组(5.0mg来曲唑+HMG治疗),各15例,对比两组治疗效果。结果相比对照组,研究组人绒毛膜促性腺激素(HCG)日≥15mm、≥18mm卵泡数量更多,HMG使用时间、卵泡成熟时间更短,HMG使用剂量更少,治疗后研究组子宫内膜厚度、血流指数更高,睾酮(T)、雌二醇(E_(2))、促黄体生成素(LH)、卵泡雌激素(FSH)水平均更高(P<0.05);两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论在PCOS患者促排卵治疗中,采用5.0mg来曲唑联合HMG治疗效果更理想。

Objective To explore the effect of different doses of letrozole combined with urinary gonadotropin(HMG)on ovulation promotion in patients with polycystic ovary syndrome(PCOS).Methods 30 patients with PCOS were screened and divided into control group(2.5 mg letrozole+HMG treatment)and research group(5.0 mg letrozole+HMG treatment)with 15 cases in each group,and the therapeutic effect of the two groups was compared.Results Compared with the control group,the human chorionic gonadotropin(HCG)daily≥15 mm and≥18 mm follicles in the study group had more follicles,the HMG use time and follicle maturation time were shorter,the HMG dosage was less,and the endometrial thickness and blood flow index were higher in the study group after treatment.The levels of testosterone(T),estradiol(E_(2)),luteinizing hormone(LH)and follicle estrogen(FSH)were higher(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In the treatment of ovulation induction in PCOS patients,5.0mg of letrozole combined with HMG is ideal.