淋巴瘤患者不同抑郁临床亚型与部分血液学指标的相关性分析

Correlation analysis between different subtypes of depression and some hematologic indicators in lymphoma patients

目的:分析淋巴瘤患者不同抑郁临床亚型抑郁程度与血液学指标的相关性。方法:对2022年1—8月在武汉大学中南医院住院治疗的74例淋巴瘤患者采用抑郁自评量表(SDS)自编问卷进行问卷调查,并收集调查当天患者的血液学指标。使用Pearson相关分析患者的抑郁评分与血液学指标的相关性。结果:55.4%的淋巴瘤患者出现了抑郁表征。淋巴瘤患者的抑郁情绪评分与血清乳酸脱氢酶之间呈显著正相关(r=0.338,P=0.008),快感缺失与血清超氧化物歧化酶之间呈显著负相关(r=-0.239,P=0.040),认知抑郁与血清钙呈显著负相关(r=-0.211,P=0.036),躯体症状和红细胞之间呈显著负相关(r=-0.322,P=0.005)。结论:血清乳酸脱氢酶、超氧化物歧化酶、钙和红细胞计数4项指标可能分别是评估抑郁情绪、快感缺失、认知抑郁和躯体症状这4种亚型抑郁程度的潜在标志物。

Objective To analyze the correlation between the degree of depression and hematologic indexes of different depression subtypes in lymphoma patients.Methods From January 2022 to August 2022,74 patients with lymphoma who were hospitalized in Zhongnan Hospital of Wuhan University were investigated by using the self⁃rating depression scale(SDS),and the hematological indexes of the patients on the survey day were collected.Pearson correlation analysis was used to analyze the correlation between patients'depression scores and hematological indicators.Results In total,74 patients with lymphoma were evaluated,55.4%had symptoms of depression.There was a significantly positive correlation between the Depressed Mood score and serum lactate dehydrogenase(r=0.338,P=0.008),and a significantly negative correlation between the anhedonia score and serum superoxide dismutase(r=-0.239,P=0.040).There was a significantly negative correlation between the cognitive depression score and serum calcium(r=-0.211,P=0.036)and between the somatic depression score and erythrocyte(r=-0.322,P=0.005).Conclusion Lactate dehydrogenase,superoxide dismutase,serum calcium,and red blood cell count may be potential markers of depressed mood,anhedonia,cognitive depression,and somatic depression.