淋巴管生成在心肌损伤修复和再生中的作用

Role of lymphangiogenesis in the repair and regeneration of myocardial injury

成熟心肌细胞缺乏再生能力,减少心肌缺血后的心肌细胞死亡、促进心肌细胞再生是治疗心肌梗死的关键。越来越多的研究表明,淋巴引流在心肌再生的过程中起着至关重要的作用。在心肌梗死发生后,促进淋巴管的生成可及时控制和消退炎症反应,有利于心脏的修复与再生。反之,若淋巴管功能缺损,则心肌水肿和纤维化加重。因此,了解心脏淋巴管的生成过程及其机制十分重要。笔者综述了心脏淋巴管的基本结构、来源以及功能,淋巴引流在心肌损伤后的作用,并总结了几种与淋巴管生成有关的分子机制,为从淋巴系统的角度促进心肌再生提供潜在思路。

Due to the lack of regeneration ability of mature cardiomyocytes,the key points for myocardial infarction therapy is to reduce cardiomyocyte death after myocardial ischemia and promote myocardial regeneration.An increasing number of studies suggest that lymphatic drainage plays a crucial role in the process of myocardial regeneration.After myocardial infarction,promoting the generation of lymphatic vessels can control and reduce the inflammatory reaction in time,which is conducive to the repair and regeneration of the heart.On the contrary,if the lymphatic vessel function is defective,the myocardial edema and fibrosis will be aggravated.Therefore,it is very important to understand the process and mechanism of cardiac lymphangiogenesis.This article reviews the basic structure,origin,and function of cardiac lymphatic vessels,the role of lymphatic drainage after myocardial injury,and summarizes several molecular mechanisms related to lymphangiogenesis,hoping to provide potential way to promote myocardial regeneration from the perspective of the lymphatic system.