肢端肥大症PitNETs的病理分型及其临床特征

Pathological subtypes and clinical features of pituitary neuroendocrine tumors presenting as acromegaly

肢端肥大症,是一种因生长激素(growth hormone,GH)过量导致的内分泌疾病,严重危害患者的健康,多由分泌GH的垂体神经内分泌肿瘤(pituitary neuroendocrine tumors,PitNETs)引起。临床表现为肢端肥大症的患者,其PitNETs的病理分型各不相同。了解肢端肥大症PitNETs不同病理分型各自的临床特征,有助于精准治疗和随访指导。本文综述了既往报道的所有临床表现为肢端肥大症的PitNETs病理分型以及其对应的病理和临床特征。

Acromegaly is an endocrine disorder caused by excessive secretion of growth hormone(GH),posing serious health risks to patients,which is mostly caused by pituitary neuroendocrine tumors(PitNETs)that secrete GH.There are varies of pathological subtypes of acromegaly patients’PitNETs.Understanding the distinct clinical features of different pathological subtypes of PitNETs presenting as acromegaly in clinical,aids in precise treatment and follow-up guidance for acromegaly patients.This review summarizes all previously reported PitNETs pathological subtypes those presenting as acromegaly in clinical,along with their corresponding pathological and clinical characteristics.