GSDME介导的细胞焦亡在肺癌治疗中作用的研究进展

Research Progress on the Role of GSDME-mediated Pyroptosis in the Treatment of Lung Cancer

目前肺癌对人类健康构成了巨大威胁。尽管有关肺癌的治疗技术近年有了显著提高,但肺癌患者的5年生存率仍然不高。在此背景下,细胞焦亡(pyroptosis)这一独特的细胞死亡机制的发现,为探索肺癌治疗的新途径提供了全新的视角。特别是成孔蛋白E(gasdermin E,GSDME)在细胞焦亡过程中扮演的角色,提示其在肺癌治疗中具有巨大的应用潜力。近年来,GSDME介导的细胞焦亡在肺癌生长、肺癌微环境中的调节作用及GSDME甲基化对肺癌治疗影响的研究取得了较大的进展,本文对这些研究进展进行了总结,并对GSDME介导的细胞焦亡在肺癌治疗中的潜力及潜在的副作用进行了分析,旨在为开发更有效的肺癌治疗策略提供理论基础。

Lung cancer causes a significant threat to human health.Despite considerable advancements in the treat-ment technologies in recent years,the five-year survival rate for lung cancer patients remains low.In this context,the discovery of pyroptosis,a unique cell death mechanism,offers a novel perspective for exploring new pathways of lung cancer treatment.Particularly,the role of gasdermin E(GSDME)in the process of pyroptosis reveals its tremendous potential in lung cancer therapy.Recent studies have made considerable progress in understanding the role of GSDME-mediated pyroptosis in lung cancer growth,the lung cancer microenvironment,and the effect of GSDME methylation on lung cancer treatment.This paper summarizes these research advancements and analyzes the potential and possible side effects of GSDME-mediated pyroptosis in lung cancer therapy,aiming to provide a theoretical foundation for developing more effective strategies for lung cancer treat-ment.