面向皮肤组织工程支架的三维多孔点阵结构制备及拉伸特性研究

PREPARATION AND TENSILE PROPERTY OF 3D POROUS LATTICE STRUCTURE FOR SKIN TISSUE ENGINEERING SCAFFOLDS

数字光处理(Digital Light Process,DLP)成型方法具有成型速度快、成型精度高的特点,能够较好用于微小尺寸结构的制备。因此,设计了一种以人工拓扑优化的正方体网格为单胞,并将该单胞沿空间进行周期性扩展,获得新型三维多孔点阵结构。配制了一种具有柔弹性的光敏树脂,选择DLP成型法进行实验制备。探究了DLP打印对该点阵结构成型的影响因素和成型效果,制备出了结构完整、无淤塞的样品,并通过该结构样品的单轴拉伸实验,研究其拉伸力学性能。结果表明,DLP打印所制备的该新型多孔结构,其内部孔隙清晰、连通性好,且孔隙率均达到了80%以上,拉伸断裂伸长率也均在85.6%以上,其中点阵结构3的拉伸韧性最大,其综合拉伸特性最优。该结构可广泛应用于皮肤组织工程支架、柔性电极、易碎品装夹夹具等。

Digital light process(DLP)forming method has the high forming speed and accuracy characteristics,and can be better used for the preparation of tiny size structures.Therefore,in this study,a new 3D porous lattice structure obtained by artificial topology⁃optimized square lattice as a single cell and spatial 3D equally spaced array of the single cell was designed.Then a flexible and elastic photosensitive resin by using DLP forming method for preparation experiments was carried out.The influence of DLP printing on the formation of the lattice structure and the forming effect were investigated.The tensile mechanical properties of all samples of complete structure without siltation were studied.The results show that the new porous structure prepared by DLP printing has clear internal pores and good connectivity in which the porosity reached more than 80%,and the elongation at break is also above 856%,among which the tensile toughness of lattice structure 3 is the largest and its comprehensive tensile properties are the best.The structure can be widely used in skin tissue engineering scaffolds,flexible electrodes,fragile product clamping fixtures,etc.