光生物疗法影响正畸牙根吸收的研究进展

Research Advances on Effect of Photobiomodulation Therapy on Root Resorption in Orthodontic Treatment.

牙根吸收是正畸治疗中最危险的并发症之一,轻度的牙根吸收可在停止加力后自行修复,而对于严重的牙根吸收尚无行之有效的应对手段。光生物疗法作为一种新的物理治疗手段,与传统方法相比,具有设备体积小、无创性、波长范围广、作用范围局限、生物安全性高等优点,其波长范围覆盖了线粒体吸收波长的范围。组织或细胞接受红光或近红外光照射后生物活性改变,上调抗炎相关因子表达,促进细胞三磷酸腺苷生成、加速局部血液微循环、促进软硬组织的修复,抑制或修复牙根吸收。光生物疗法的疗效取决于其波长、能量密度、功率密度、照射频率四个要素,遵循“Arndlt-Schulz”定律,即“双向剂量效应”,生物疗效具有参数相关性,因而难以确定最佳使用参数。但光生物疗法独特的优势,使其在正畸领域有着巨大的应用潜力。

Root resorption is one of the most dangerous complications during orthodontic treatment.Mild root resorption can be repaired after removing force.However,there is no effective measure for severe root resorption.Photobiomodulation therapy,as a new physical therapy,has the advantages of small size,non-invasion,wide wavelength,limited scope of action,and biological safety.The range of its wavelength covers the range of mitochondrial absorption wavelength,and the biological activity of tissues or cells changes after being irradiated by red or near-infrared light,upregulating the anti-inflammatory and other related factors,promoting cellular ATP production,accelerating local blood microcirculation,promoting the repair of soft and hard tissues,and inhibiting or repairing resorbed tooth.The effect of photobiomodulation therapy depends on four elements,i.e.the parameter of the wavelength,energy density,power density,and irradiation frequency,obeying the"biphasic dose effect".Biological efficacy is parameter dependent,making it difficult to obtain optimal parameters.However,the unique advantages of photobiomodulation therapy make it have great application potential in the field of orthodontics.