紫色杆菌素调控机制与产量优化的研究进展

Research Progress on the Regulatory Mechanism and Yield Optimization of Violacein

紫色杆菌素(violacein)是某些特殊微生物代谢过程中产生的一种蓝紫色吲哚衍生物,具有干扰生物膜、抑制细胞增殖、抗氧化、抗炎等生物活性,是极具开发价值的天然微生物紫色色素,在抑菌、抗肿瘤、抗病毒、生物染料等方面具有广泛的应用。野生型原始菌株产紫色杆菌素普遍存在产量低、产量不稳定等缺陷,制约了紫色杆菌素的工业化生产及应用。对紫色杆菌素的生物活性、基因组成、基因调控和产量提高等方面进行总结,旨在为进一步通过生物技术手段提高紫色杆菌素的产量提供理论基础。

Violacein is a blue-violet indole derivative produced by microbial metabolism,which has shown beneficial biological activities,including the interference with biological membranes,inhibition of cell proliferation,antioxidant,and anti-inflammatory activities.It has been widely applied to antimicrobial,anti-tumor,and anti-viral activities and bio-pigments.However,the industrial application of natural violacein has been hampered by low and unstable yields.This review summarizes the biological activity,genomic composition,gene regulation,and yield optimization of violacein.It can serve as a reference for further improving the yield of violacein through genetic engineering.