头孢呋辛钠与头孢唑肟钠对治疗急性支气管肺炎患儿的应用效果及VCAM-1、IFN-γ水平影响

Application Effect of Cefuroxime Sodium and Ceftizoxime Sodium in the Treatment of Children with Acute Bronchial Pneumonia and VCAM-1,IFN-γHorizontal Impact

目的探讨头孢呋辛钠与头孢唑肟钠治疗对急性支气管肺炎患儿的应用效果及动物血管细胞黏附分子-1(VCAM-1)、γ干扰素(IFN-γ)水平影响。方法选取2021年8月—2023年7月韩城市妇幼保健院收治的82例支气管肺炎患儿作为研究对象,所有患儿均采取常规维持水电解质、酸碱平衡、吸痰、清热、平喘、止咳等对症治疗,并采取布地奈德雾化吸入治疗。同时对其进行病原菌培养和药物敏感性测试,其中41例患儿对头孢呋辛钠敏感性较高,对其采取头孢呋辛钠治疗,将其分为头孢呋辛钠组,另外41例患儿对于头孢唑肟钠敏感,采取头孢唑肟钠治疗,将其分为头孢唑肟钠组。比较两组患儿肺部啰音/喘鸣音消失时间、咳嗽消失时间、发热总天数、影像学恢复时间,比较治疗前后VCAM-1、IFN-γ、PCT、CRP表达水平,并比较两组患儿治疗过程中不良反应发生情况。结果头孢呋辛钠组患儿肺部啰音/喘鸣音消失时间、咳嗽消失时间、发热总天数、影像学恢复时间明显短于头孢唑肟钠组,差异有统计学意义(P<0.05);治疗前,两组患儿VCAM-1、IFN-γ、PCT、CRP表达水平比较,差异无统计学意义(P>0.05);治疗后,两组患儿VCAM-1、PCT、CRP水平均降低,且头孢呋辛钠组组低于头孢唑肟钠组,IFN-γ水平均升高,头孢呋辛钠组高于头孢唑肟钠组,差异有统计学意义(P<0.05);两组患儿均无肾功能损伤、血液系统损伤等严重不良反应发生,且恶心呕吐、头晕、皮肤过敏、腹泻等不良反应发生率比较,差异无统计学意义(P>0.05)。结论头孢呋辛钠对于急性支气管肺炎患儿的应用效果优于头孢唑肟钠,可缩短患儿症状持续时间,缓解炎症细胞因子聚集,降低机体炎症反应,且安全性较高。

Objective Objective to investigate the application effect of cefuroxime sodium and ceftizoxime sodium in the treatment of children with acute bronchial pneumonia and the animal vascular cell adhesion molecule-1(VCAM-1)and its clinical significanceγInterferon(IFN-γ)Horizontal impact.Methods All 82 children with bronchopneumonia admitted to Hancheng Maternal and Child Health Hospital from August 2021 to July 2023 were selected for retrospective analysis,and randomly divided into cefuroxime sodium group and ceftizoxime sodium group,41 cases in each group.All children were treated with routine maintenance of water electrolyte,acid-base balance,sputum suction,heat clearing,asthma relieving,cough relieving and other symptomatic treatment,and were treated with budesonide atomization inhalation and azithromycin oral treatment.The children in Cefuroxime Sodium group were given cefuroxime sodium intravenous drip on the basis of conventional treatment,while the children in ceftizoxime sodium group were given ceftizoxime sodium intravenous drip on the basis of conventional treatment.The disappearance time of pulmonary rales/wheezes,cough,total days of fever,imaging recovery time,VCAM-1 and IFN before and after treatment were compared between the two groups-γ,The expression levels of PCT and CRP were compared between the two groups.Results The disappearance time of pulmonary rales/wheezes,cough,total days of fever and imaging recovery time in Cefuroxime Sodium group were significantly lower than those in ceftizoxime sodium group(P<0.05);VCAM-1 and IFN of the two groups before treatment-γ.There was no significant difference in the expression levels of PCT and CRP between the two groups(P>0.05).After treatment,the levels of VCAM-1,PCT and CRP in the two groups were decreased,and the level of IFN in the cefuroxime sodium group was lower than that in the ceftizoxime sodium group-γThe serum level in Cefuroxime Sodium group was higher than that in ceftizoxime sodium group(P<0.05);No severe adverse reactions such as renal function injury and blood system injury occurred in the two groups,and there was no significant difference in adverse reactions such as nausea and vomiting,dizziness,skin allergy and diarrhea between the two groups(P>0.05).Conclusion Cefuroxime sodium is better than ceftizoxime sodium in the application of children with acute bronchial pneumonia,which can shorten the duration of symptoms,relieve the accumulation of inflammatory cytokines,reduce the body's inflammatory reaction,and has high safety.