近红外脑功能成像在帕金森病中的应用与进展

Application and Progress of Near-Infrared Brain Function Imaging in Parkinson’s Disease

帕金森病属于神经退行性疾病,临床异质性高,诊断主要依据临床症状及少量影像学证据,早期诊治困难。近红外脑功能成像技术是新兴的光学影像学技术,可间接反映大脑代谢活动的变化。目前帕金森病患者在大多数基于近红外脑功能成像技术的运动任务研究中表现出额叶的激活增强,体现了额叶在帕金森病中的代偿作用。近年来近红外脑功能成像研究范围逐渐拓展至帕金森病的非运动症状和脑连接分析领域,目前关于这一领域的研究较少,有很大的研究空间。现在就近红外脑功能成像技术在帕金森病临床症状、治疗康复中的应用进行综述,以期对未来帕金森病的研究提供帮助。

Parkinson’s disease(PD)is a neurodegenerative disorder characterized by high clinical heterogeneity.Its diagnosis primarily relies on clinical symptoms and limited imaging evidence,making early diagnosis and treatment challenging.Functional near-infrared spectroscopy(fNIRS)is an emerging optical imaging technique that can indirectly reflect changes in brain metabolic activity.Currently,patients with PD exhibit enhanced activation of the frontal lobe in most studies involving motor tasks based on fNIRS,demonstrating the compensatory role of the frontal lobe in PD.In recent years,the scope of fNIRS research has gradually expanded to include non-motor symptoms and brain connectivity analysis in PD,a field that currently has limited research but offers significant potential for further study.This review focuses on the application of fNIRS in the clinical symptoms and rehabilitation treatment of PD,aiming to provide assistance for future research on PD.