银杏叶提取物治疗气滞血瘀证突发性耳聋临床效果

Clinical Effect of Ginkgo Leaf Extract on Sudden Deafness with Qi Stagnation and Blood Stasis

目的研究银杏叶提取物治疗气滞血瘀证突发性耳聋的临床效果。方法该院2018年1月—2021年12月收治的84例气滞血瘀证突发性耳聋患者采用随机数字表法分为巴曲酶组(42例)和联合银杏叶组(42例)。巴曲酶组采用巴曲酶进行治疗,在巴曲酶组的基础上,联合银杏叶组采用银杏叶提取物进行治疗,两组均治疗10 d。统计两组治疗10 d后的疗效及治疗期间不良反应发生情况,比较两组治疗前及治疗10 d后中医证候积分、凝血功能、血液流变学及听力情况。结果治疗10 d后,联合银杏叶组总有效率高于巴曲酶组(P<0.05)。治疗10 d后与治疗前比较,两组恶心呕吐、耳鸣、耳闷胀感、眩晕评分及血清纤维蛋白原(serum fibrinogen,FIB)、血小板因子(platelet factor,PF)水平、全血黏度(whole blood viscosity,WBV)、血细胞比容(hemocyte volume,HCT)、听力阈值、听力损失评分降低,联合银杏叶组低于巴曲酶组(P<0.05);两组凝血酶原时间(prothrombin time,PT)、部分凝血酶活时间(partial thrombin active time,APTT)延长,联合银杏叶组长于巴曲酶组(P<0.05)。治疗期间,联合银杏叶组总不良反应发生率与巴曲酶组比较,差异无统计学意义(P>0.05)。结论银杏叶提取物治疗气滞血瘀证突发性耳聋,可有效改善患者中医证候、凝血功能、血液流变学,提高其听力,疗效较好,同时具有良好的安全性。

Objective To study the clinical effect of ginkgo leaf extract on sudden deafness with Qi stagnation and blood stasis.Methods A total of 84 patients with sudden deafness with Qi stagnation and blood stasis syndrome admitted to the hospital from January 2018 to December 2021 were divided into batroxase group(42 cases)and combined ginkgo leaf group(42 cases)by the random number table method.The batroxase group was treated with batroxase,and the combined ginkgo leaf group was treated with ginkgo leaf extract on the basis of the batroxase group.Both groups were treated for 10 d.The efficacy of the two groups after 10 d of treatment and the occurrence of adverse reactions during the treatment were counted,and the scores of traditional Chinese medical syndromes,coagulation function,hemorheology and hearing of the two groups were compared before and after 10 d of treatment.Results After 10 d of treatment,the total effective rate of the combined ginkgo leaf group was higher than that of the batroxase group(P<0.05).After 10 d of treatment,the scores of nausea and vomiting,tinnitus,ear bloating and vertigo,the levels of serum fibrinogen(FIB),platelet factor(PF),whole blood viscosity(WBV),hemocyte volume(HCT),hearing threshold and score of hearing loss decreased in both groups compared with those before treatment,and the levels of the above indexes of the combined ginkgo leaf group were lower than those in the batroxase group(P<0.05).The prothrombin time(PT)and partial thrombin active time(APTT)prolonged in both groups,and the time of the combined ginkgo leaf group was longer than that in the batroxase group(P<0.05).During treatment,there was no significant difference in the incidence of total adverse reactions between the combined ginkgo leaf group and the batroxase group(P>0.05).Conclusion The ginkgo leaf extract in the treatment of sudden deafness with Qi stagnation and blood stasis could effectively improve the traditional Chinese medical syndromes,coagulation function,hemorheology and the hearing of the patients,with good curative effect and good safety.