半夏泻心汤治疗胃病研究进展

Research Progress of Banxia Xiexin Decoction(半夏泻心汤)in Treatment of Gastropathy

仲景所创半夏泻心汤为辛开苦降代表方,广泛用于消化系统疾病。近年来,慢性胃炎、消化性溃疡等胃部相关疾病的发病率日渐增长,降低患者生活质量,加重医疗卫生负担。查阅文献发现半夏泻心汤治疗胃病的临床及机制研究均取得较大进展,但缺乏对其相关文献的系统整理,导致该方治疗胃病的价值未能及时被进一步挖掘和利用。半夏泻心汤在治疗胃病方面具有有效缓解症状、降低复发率、不良反应少等优势;主要通过抗炎杀菌、调节免疫功能、修复黏膜损伤、抗肿瘤、调节胃肠激素、促胃肠动力等途径发挥治疗作用,但具体分子作用机制仍需进一步探索。因此,该文从理论探索、临床研究和作用机制方面对近年来半夏泻心汤治疗胃病的进展进行阐述,为临床防治胃病及深入研究其作用机制提供参考依据。

Banxia Xiexin Decoction(半夏泻心汤),created by Zhongjing,is a representative prescription of pungent dispersing and bitter descending,widely used in digestive system diseases.In recent years,the incidence rate of stomach related diseases such as chronic gastritis and peptic ulcer is increasing,which reduces the quality of life of patients and increases the burden of medical care.Through literature review,it is found that the clinical and mechanism researches of Banxia Xiexin Decoction in the treatment of gastric diseases have made great progress,but the lack of systematic collation of its related literature leads to the failure of further exploring and utilizing its value in the treatment of gastric diseases in a timely manner.Banxia Xiexin Decoction has the advantages of effectively relieving symptoms,reducing the recurrence rate and less adverse reactions in the treatment of gastric diseases.It mainly exerts its therapeutic effect through anti inflammation and sterilization,regulating immune function,repairing mucosal damage,anti-tumor,regulating gastrointestinal hormones,promoting gastrointestinal motility and other ways,but the specific molecular mechanism of action still needs further exploration.Therefore,this article expounded the progress of Banxia Xiexin Decoction in treating gastric diseases in recent years from the aspects of theoretical exploration,clinical research and mechanism of action,providing reference for clinical prevention and treatment of gastric diseases and in-depth study of its mechanism of action.