日本小太郎公司研制汉方颗粒剂历史过程考察

Historical Process Review on Kotaro Company’s Preparing Kampo Granules

1967年6月,小太郎公司成功将6种汉方颗粒剂纳入日本医疗保险体系,这一成就得益于公司创始人上田太郎的人生经历及其广泛的社交网络。上田太郎源于“奶粉说”的制作理念,可能受到了经方学者藤平健的影响;医史学者石原明推动了公司从家族企业向现代公司的转型;关东名医矢数道明和大塚敬节为小太郎公司的汉方理论和临床应用提供了支持;药剂师山元章平建议开发颗粒剂,使公司产品中含有大量仲景处方;药学专家木村康一和高桥真太郎确保了颗粒剂制作的技术实力,桑野重昭则是产品成功制作的关键人物;医师会会长武见太郎积极推动了颗粒剂进入医保。通过探讨上田太郎及其团队努力促使汉方颗粒剂制作从梦想变为现实的历史过程,旨在为当代剂型研发等研究提供参考。

In June 1967,Kotaro Company successfully incorporated six kinds of Kampo granules into the Japanese health insurance system,an achievement that benefited from the life experience of company founder Ueda Taro and his extensive social network.His production concept originated from“milk powder theory”,which may have been influenced by the traditional formula scholar Fujihira Ken.Ishihara Akira,a medical historian,promoted the company’s transformation from a family business to a modern company.Famous Kanto doctors Yakazu Domei and Otsuka Yosinori provided support on Kampo theories and clinical application for the company.Pharmacist Yamamoto Shohei suggested developing granules so that the company’s products would contain a large amount of prescriptions and formulas from Zhang Zhongjing.Pharmaceutical experts Kimura Koichi and Takahashi Shintaro ensured the technical strength of the production of granules,and Shigeaki Samno is the key person for the successful production of products.Takemi Taro,president of the Medical Doctors’Association,has pushed for the inclusion of granules in health insurance with efforts.This paper discusses the historical process of making Kampo granules from dream to reality under the efforts of Ueda Taro and his team,aiming to provide reference for the research of contemporary dosage forms.