基于MAPK信号通路的中药治疗急性胰腺炎作用机制研究进展

Research progress on traditional Chinese medicine in treatment of acute pancreatitis by MAPK signaling pathway

随着对急性胰腺炎(acute pancreatitis,AP)的深入研究,具有成分丰富、靶点众多特点的中药,被发现在调节机体免疫炎症反应中发挥着重要的作用,并为治疗AP提供关键方向。本文通过对近年相关文献的搜集梳理发现,由细胞外调节蛋白激酶(extracellular regulated protein kinases,ERK)1/2、c-Jun氨基末端激酶(c-Jun N-terminal kinase,JNK)、p38丝裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)三条主要子通路构成的MAPK信号通路在抑制炎症反应、抗氧化应激、促进细胞凋亡等方面具有显著的作用。近年来,中医药领域以MAPK信号通路为起点,发挥辨病辨证特色优势对中药方剂、中药单体、中药提取物及中药活性成分等干预AP中MAPK信号通路进行了大量的研究,并将中药治疗AP的机制归纳为调控炎症因子、介导信号因子表达以抑制炎症级联反应;通过减少活性氧产生和释放、调控氧化酶的活性达到抑制氧化应激反应;增加线粒体膜通透性调节半胱氨酸天冬氨酸蛋白酶3(Caspase-3)、B淋巴细胞瘤-2(B-cell lymphoma-2,Bcl-2)和Bcl-2相关X蛋白(Bcl-2 associated X,Bax)等蛋白与基因的表达、诱导内质网应激,进而平衡细胞凋亡,达到减轻胰腺损伤的作用。因此,本文针对目前基于MAPK信号通路中药治疗AP的相关文献进行总结分析,旨在为今后治疗AP的研究提供一定的参考。

With the deep research of acute pancreatitis(AP),Chinese acute pancreatitis with abundant components and numerous targets have been found to play an important role in regulating the immune inflammatory response,and provide the key direction for the treatment of AP.In this paper,through the collection of relevant literature in recent years,the mitogen-activated protein kinase(MAPK)signaling pathway,which is composed of extracellular regulated protein kinases(ERK1/2),c-Jun N-terminal kinase(JNK)and p38 MAPK,plays a significant role in inhibiting inflammatory reaction,anti-oxidative stress and promoting apoptosis.In recent years,MAPK signal pathway has been used as a starting point in traditional Chinese medicine,taking advantage of the characteristics of disease differentiation and syndrome differentiation,we have done a lot of research on the interference of MAPK signal pathway in AP by traditional Chinese medicine prescription,monomer,extract of traditional Chinese medicine and active ingredient of traditional Chinese medicine,the mechanism of traditional Chinese medicine(TCM)in the treatment of AP was summarized as regulating inflammatory factors and mediating the expression of signal factors to inhibit the inflammatory cascade reaction Through reducing the production and release of reactive oxygen species and regulating the activity of oxidase to inhibit oxidative stress;The increase of mitochondrial membrane permeability can regulate the expression of caspase-3,B-cell lymphoma-2(Bcl-2)and Bcl-2 associated X(Bax),induce endoplasmic reticulum(ER)stress,balance apoptosis,and alleviate pancreatic injury.Therefore,this paper aims to summarize and analyze the current literatures on the treatment of AP with Chinese herbal medicine based on MAPK signal pathway,in order to provide some references for the future research on the treatment of AP.