摘要
肾草酸钙结石是泌尿系统最常见的疾病。现从影响尿液中代谢物、抑制晶体生长、改变晶体物相、调节蛋白活性、抗氧化等方面综述柠檬酸及其衍生物防治肾草酸钙结石的可能机制,为口服药物治疗肾结石的临床提供参考。
Calcium oxalate kidney stones represent the most prevalent disease of the urinary system.This article reviews the possible mechanisms of citric acid and its derivatives in preventing and treating renal calcium oxalate stones from five aspects:Affecting metabolites in urine,inhibiting crystal growth,changing crystal phase,regulating protein activity,and antioxidation.This provides a basis and reference for the clinical application of oral medication in the treatment of renal stones.
作者
贾寅强
赵明雪
赵磊
续艳丽
张启立
李娇娇
徐富梅
JIA Yinqiang;ZHAO Mingxue;ZHAO Lei;XU Yanli;ZHANG Qili;LI Jiaojiao;XU Fumei(Gansu Province Engineering Laboratory for TCM Standardization Technology and Popularization,Key Laboratory of Chemistry and Quality for TCM of Colleges of Gansu Province,Gansu University of TCM,Lanzhou,Gansu,730000 P.R.China;Longyao Industry Innovation Research Institute,Northwest Collaborative Innovation Center for TCM,Gansu University of TCM,Lanzhou,Gansu,730000 P.R.China;Lanzhou Institute of Food and Drug Control,Lanzhou,Gansu,730000 P.R.China)
出处
《华西药学杂志》
CAS
CSCD
北大核心
2024年第4期492-496,共5页
West China Journal of Pharmaceutical Sciences
基金
国家自然科学基金资助项目(批准号:82160457
81660577)
甘肃省自然科学基金项目(21JR7RA564)。
关键词
肾结石
草酸钙
柠檬酸
衍生物
药物治疗
作用机制
研究进展
Kidney stones
Calcium oxalate
Citric acid
Derivatives
Drug therapy
Mechanism
Research progress
