多环芳烃在炎症性皮肤病发生发展中的作用研究进展

Role of polycyclic aromatic hydrocarbons in the occurrence and development of inflammatory skin diseases

多环芳烃(PAH)是含两个以上苯环的化合物,广泛存在于环境之中,可通过各种途径影响人体健康。以往PAH对健康影响研究多集中在其致癌性、致畸性以及对肺部疾病、心血管疾病等的影响,近年来PAH对炎症性皮肤病(尤其是银屑病、特应性皮炎和红斑狼疮)的影响日益受到重视。本文综述PAH对炎症性皮肤病的研究进展。

Polycyclic aromatic hydrocarbons(PAHs)are compounds with more than two benzene rings,widely exist in the environment,and can affect human health in various ways.Previous studies on the health effects of PAHs mainly focused on their carcinogenicity,teratogenicity,and effects on pulmonary diseases,cardiovascular diseases,etc.In recent years,increasing attention has been paid to the negative influence of PAHs to inflammatory skin diseases(especially psoriasis,atopic dermatitis,and lupus erythematosus).This review summarizes recent research advances in the role of PAHs in the occurrence and development of inflammatory skin diseases.