穿山龙随证施量策略在降低桥本甲状腺炎自身抗体治疗中的运用

Application of Ningpo yam rhizome in reducing Hashimoto's thyroiditis autoantibodies based on the strategy of determining dosage according to syndromes

通过分享仝小林院士使用穿山龙降低甲状腺球蛋白抗体(thyroglobulin antibody,TGAb)和甲状腺过氧化物酶抗体(thyroid peroxidase antibody,TPOAb)的一则病案,分析其随证施量策略。在慢性疾病长期用药的调量过程中,除“病重药重、病轻药轻”“不效加量”“中病即止/减”“效不更方”策略外,初始加量应谨慎,“慢加快减”也是重要的随证施量策略。

This article presents a case of decreasing thyroglobulin antibody(TGAb)and thyroid peroxidase antibody(TPOAb)using Ningpo yam rhizome by Academician Tong Xiaolin,and analyses the strategies of determining dosage according to syndromes.The study concludes that in the process of dosage adjustment for chronic diseases,in addition to the strategies of"treating severe diseases with high dose and treating mild diseases with low dose","increasing dosage in case of ineffectiveness","ceasing medication or reducing dosage once a prescription taking effect",and"not changing the dosage in case of effectiveness",the initial dosage increasing should be handled with caution,with"increasing dosage slowly and reducing dosage rapidly"as an important strategy in dosage adjustment based on syndromes.