益气固本胶囊治疗儿童哮喘缓解期肺脾气虚证

Clinical effifficacy of Yiqi Guben Capsules in the treatment of children with asthma in remission with a lung-spleen qi defificiency syndrome

目的观察益气固本胶囊治疗儿童哮喘缓解期肺脾气虚证的临床疗效。方法将200例患儿随机分为治疗组和对照组,各100例,治疗组给予益气固本胶囊口服,对照组给予保儿宁颗粒口服,疗程为3个月,治疗结束后观察患儿中医证候(气短自汗、面色少华或萎黄、神疲懒言、纳呆便溏、舌质淡,苔白,脉缓)改善情况,实验室检查患儿血清中嗜酸性炎症和免疫相关指标(EOS、IgA、IgE及IgG含量)、呼出气中一氧化氮(FeNO、nNO)浓度和肺功能(PEF日间变异率、FEV1/FVC)变化情况;随访1年,观察1年内哮喘发病次数及反复呼吸道感染次数。结果治疗3个月后,2组患儿中医证候、血清中嗜酸性炎症和免疫相关指标(EOS、IgA、IgE及IgG含量)、呼出气中一氧化氮(FeNO、nNO)浓度和肺功能(PEF日间变异率、FEV1/FVC)较治疗前有明显改善,且治疗组优于对照组(P<0.05);治疗结束后1年内,治疗组总有效率为90.00%,对照组为81.00%,差异具有统计学意义(P<0.05);治疗组患儿哮喘发作次数、反复呼吸道感染次数明显降低,与对照组比较,差异具有统计学意义(P<0.05)。结论益气固本胶囊短期可以改善哮喘患儿肺脾气虚型体质、减轻嗜酸性粒细胞炎症、调节免疫功能、改善肺功能,长期可以控制儿童哮喘反复发作,同时可以减少肺炎等呼吸道疾病的发病。

Objective To observe the clinical efficacy of Yiqi Guben Capsules in the treatment of children with asthma in remission with a syndrome of qi deficiency of the lung and spleen.Methods A total of 200 children were randomly divided into two groups,the treatment group and the control group,with 100 cases in each group.The treatment group was given Yiqi Guben Capsules orally,while the control group was given Baoerning Granules orally,both for 3 months.After treatment,the improvement of TCM syndromes(shortness of breath and sweating,pale or yellowish complexions,fatigue and lazy speech,anorexia and loose stools,pale tongue,white coatings,slow pulse)was observed.The changes in the serum eosinophilic inflammation and immune-related indexes(EOS,IgA,IgE and IgG contents),nitric oxide(FeNO,nNO)concentrations in exhaled breath and lung function(PEF diurnal variability,FEV1/FVC)were examined in the laboratory.The follow-up in them was conducted for one year,and the number of asthma episodes and recurrent respiratory tract infections was observed within one year.Results After 3 months of treatment,the TCM syndromes(shortness of breath and sweating,pale or yellowish complexions,fatigue and lazy speech,anorexia and loose stools,pale tongue,white coatings,slow pulse)were significantly improved in children in the treatment group.Laboratory tests showed a significant change in the serum eosinophilic inflammation and immune related indicators(EOS,IgA,IgE,and IgG contents),nitric oxide(FeNO,nNO)concentrations in exhaled breath,and lung function(PEF diurnal variability rate,FEV1/FVC)in children in the treatment group,compared to before treatment(P<0.05).Within one year after treatment,the total effective rate was 90.00%in children in the treatment group,and the number of asthma attacks was significantly reduced,with a statistically significant difference compared with before treatment(P<0.05).Within one year after treatment,the number of recurrent respiratory tract infections was significantly reduced in the treatment group,with a statistically significant difference compared to before treatment(P<0.05).Conclusion Yiqi Guben Capsules is an effective drug for the treatment of asthma in children,which can improve the lung-spleen qi deficiency syndrome,reduce eosinophil inflammations,regulate immune function,and improve lung function in children with asthma in the short term,and can control repeated asthma attacks in them in the long term,and can reduce the incidence of respiratory diseases,such as pneumonia.