循经电针联合穴位注射治疗突发性聋的疗效观察

Efficacy observation of along-meridian electroacupuncture combined with point injection for sudden hearing loss

目的观察瘈脉和耳门穴循经电针联合颅息穴穴位注射甲泼尼龙琥珀酸钠治疗突发性聋的临床疗效。方法选取120例突发性聋患者,按随机数字表法分为对照组和观察组,每组60例。两组均予常规治疗,对照组采用颅息穴穴位注射甲泼尼龙琥珀酸钠治疗,观察组在对照组治疗基础上联合瘈脉和耳门穴循经电针治疗。比较两组听力和耳鸣的临床疗效以及不良反应发生情况,观察两组治疗前后中医证候积分以及血清可溶性血管内皮细胞黏附分子-1(soluble vascular cell adhesion molecule-1,sVCAM-1)、一氧化氮(nitrogen oxide,NO)和超氧化物歧化酶(superoxide dismutase,SOD)水平的变化。结果观察组听力和耳鸣总有效率均高于对照组(P<0.05)。两组治疗后中医证候积分均降低(P<0.05),且观察组均低于对照组(P<0.05)。两组治疗后血清sVCAM-1水平均降低(P<0.05),且观察组低于对照组(P<0.05);两组治疗后血清NO和SOD水平均升高(P<0.05),且观察组高于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论在常规治疗基础上,瘈脉和耳门穴循经电针联合颅息穴穴位注射甲泼尼龙琥珀酸钠治疗突发性聋的临床疗效优于单一穴位注射,可有效改善患者症状,可能与其调节血清sVCAM-1、NO和SOD水平有关。

Objective To observe the clinical efficacy of along-meridian electroacupuncture at Chimai(TE18)and Ermen(TE21)plus point injection of Methylprednisolone sodium succinate at Luxi(TE19)in treating sudden hearing loss.Method One hundred and twenty patients with sudden hearing loss were recruited and divided into a control group and an observation group using the random number table method,with 60 cases in each group.Both groups received the conventional treatment.The control group was treated with point injection of Methylprednisolone sodium succinate at Luxi,and the observation group additionally received along-meridian electroacupuncture at Chimai and Ermen.The clinical efficacy in hearing and tinnitus and adverse reactions were compared between the two groups.Both groups were observed before and after the treatment for changes in the symptom score of traditional Chinese medicine(TCM)and serum levels of soluble vascular cell adhesion molecule-1(sVCAM-1),nitrogen oxide(NO),and superoxide dismutase(SOD).Result The observation group was higher than the control group in comparing the total effective rates in hearing and tinnitus(P<0.05).After the treatment,the TCM symptom score declined in both groups(P<0.05)and was lower in the observation group than in the control group(P<0.05);the serum sVCAM-1 level dropped in the two groups (P<0.05) and was lower in the observation group compared to the control group (P<0.05);the serum NO and SOD levels increased in both groups (P<0.05) and were higher in the observation group than in the control group (P<0.05). There was no significant difference in the adverse reaction rate between the two groups (P>0.05). Conclusion Based on the conventional treatment, along-meridian electro-acupuncture at Chimai and Ermen plus point injection of Methylprednisolone sodium succinate at Luxi produces better clinical efficacy in treating sudden hearing loss compared to the sole use of point injection. This method can effectively improve the patient’s symptoms, which may be associated with its regulation of serum levels of sVCAM-1, NO, and SOD.