m6A甲基化修饰及其生物学功能

Methylation modification of m6A and its biological functions

m6A甲基化修饰是真核生物中最常见的RNA修饰之一,由甲基转移酶、去甲基化酶和甲基化阅读蛋白共同调控,参与调控神经发育、免疫稳态、昼夜节律控制等生理过程。本文拟从m6A甲基化修饰的概念、调节酶系和生物学功能三方面进行简要概述,旨在为高中生物学表观遗传的相关教学提供资料。

M6A methylation modification is one of the most common RNA modifications in eukaryotes,jointly regulated by methyltransferases,demethylases,and methylated reading proteins,involved in regulating physiological processes such as neural development,immune homeostasis,and circadian rhythm control.In this paper,the concept of m6A methylation modification,regulatory enzyme system and biological functions are briefly reviewed,in order to provide information for the teaching of biological epigenetics in high school.