2003-2020年新乡市中心医院乳腺癌临床流行病学特征变化趋势

Trend of Clinical Epidemiological Characteristics of Breast Cancer in Xinxiang Central Hospital from 2003 to 2020

目的分析2003—2020年新乡市中心医院乳腺癌流行病学特征的变化趋势,为新乡市乳腺癌的防治及研究工作提供参考依据。方法收集新乡市中心医院2003—2020年首次确诊并住院治疗的女性原发性乳腺癌患者的临床及病理资料,建立乳腺癌患者数据库。回顾性分析医院女性乳腺癌住院患者例数、确诊年龄、临床分期、分子分型和手术方式等临床特征及其变化趋势。结果共收治5451例女性乳腺癌住院患者,对5097例患者纳入年龄分析,确诊中位年龄为52岁,46~50岁为高发年龄段(948例,17.39%);≤35岁(年轻乳腺癌患者)占比为5.32%(271例),≤25岁(极年轻乳腺癌患者)占比为0.24%(12例);确诊时临床分期以Ⅰ期(24.91%)、Ⅱ期(49.44%)为主;将有完整、准确病理资料的3947例患者纳入分子分型分析,Luminal型2838例(71.90%)、三阴型590例(14.95%)、HER-2阳性型519例(13.15%);手术方式以乳腺癌改良根治术为主,2010年出现了保乳手术,保乳手术占比从2010年的0.36%上升到2020年的21.91%,2015年开始了前哨淋巴结活检术,实施占比从2015年的13.54%上升到2020年的57.57%。结论2003—2020年新乡市中心医院女性乳腺癌住院患者例数呈逐年递增趋势,高发年龄段为46~50岁,确诊中位年龄呈递增的趋势,年轻乳腺癌患者占比变化趋势稳定,临床分期以早期为主,Ⅰ期占比有所上升,Ⅲ期占比呈下降趋势,0期和Ⅳ期占比趋势变化保持平稳,Luminal型乳腺癌患者占比最高,并呈逐年递增的趋势,保乳术和前哨淋巴结活检术手术占比逐年增多。

Objective To analyze the changing trend of epidemiological characteristics of breast cancer in Xinxiang Central Hospital from 2003 to 2020,in order to provide reference for the prevention,treatment and research of breast cancer in Xinxiang.Methods Clinical and pathological datas of female patients with primary breast cancer who were diagnosed and hospitalized for the first time in Xinxiang Central Hospital from 2003 to 2020 were collected,and a database of breast cancer patients was established.The clinical characteristics and trends of inpatients with female breast cancer,such as the number of cases,age of diagnosis,clinical stage,molecular classification and surgical methods were analyzed retrospectively.Results A total of 5451 inpatients with female breast cancer were admitted,of which 5097 patients were included in the age analysis,and the median age of diagnosis was 52 years old,with a high prevalence age between 46-50 years old(948 cases,17.39%).The proportion of≤35 years old(young breast cancer patients)was 5.32%(271 cases),and the proportion of≤25 years old(very young breast cancer patients)was 0.24%(12 cases).The clinical stages were mainly stageⅠ(24.91%)and stageⅡ(49.44%).A total of 3947 patients with complete and accurate pathological datas were included in molecular typing analysis,including 2838(71.90%)Luminal type,590(14.95%)triple-negative type,and 519(13.15%)HER-2 positive type.The main surgical methods were modified radical mastectomy,breast conserving surgery appeared in 2010,and the proportion of breast conserving surgery increased from 0.36%in 2010 to 21.91%in 2020.Sentinel lymph node biopsy began in 2015,and the proportion of implementation increased from 13.54%in 2015 to 57.57%in 2020.Conclusion The number of female breast cancer inpatients in Xinxiang Central Hospital from 2003 to 2020 showed an increasing trend year by year.The high incidence age was 46-50 years old,and the median age of diagnosis showed an increasing trend.The proportion of young breast cancer patients was stable.The clinical stages were mainly early stage,the proportion of stageⅠincreased,the proportion of stageⅢdecreased,and the proportion of stage 0 and stageⅣremained stable.The number of Luminal breast cancer patients accounted for the largest proportion,and showed an increasing trend year by year.The proportion of breast conserving operation and sentinel lymph node biopsy increased year by year.