大黄[庶虫]虫丸临床应用及实验研究进展

Clinical Application and Experimental Research Progress of Dahuang Zhechong Pill(大黄[庶虫]虫丸)

大黄[庶虫]虫丸为张仲景治疗虚劳干血的有效方剂。该方是在抵挡汤的基础上加苦杏仁、黄芩、地黄、白芍等8味中药组成,具有活血破瘀、缓中补虚之功,即峻药丸服,以缓攻瘀血,瘀血去则新血生,最终达扶正不留瘀、祛瘀不伤正的目的。适用于虚劳后期、因虚致瘀之证,故此方兼具扶正与祛邪双重功效。临床运用方面,单用大黄[庶虫]虫丸治疗相关疾病的报道偏少,多以其加减方或联合其他方剂或联合西药,治疗肝、心、肺、肾、妇科、男科等各类疾病。实验研究方面,大黄[庶虫]虫丸具有抗炎、抗纤维化,改善血糖、改善血脂、改善血管功能,改善微循环等作用,多针对某一具体疾病探讨其作用、机制,故其物质基础研究相对薄弱。通过查阅近10年大黄[庶虫]虫丸临床应用及实验研究情况,对其临床应用及实验研究进展进行归纳总结,为大黄[庶虫]虫丸深入研究、运用提供参考。

Dahuang Zhechong Pill(大黄[庶虫]虫丸)is an effective prescription of ZHANG Zhongjing for treating asthenia and dried blood.The prescription is composed of 8 kinds of Chinese herbs,such as Kuxingren(Armeniacae Semen Amarum),Huangqin(Scutellariae Radix),Dihuang(Rehmanniae Radix)and Baishao(Paeoniae Radix Alba)based on Didang Decoction(抵挡汤).It has the function of promoting blood circulation,breaking blood stasis,soothing the middle and tonifying deficiency,that is,taking the drug with strong efficacy with pills to slow down the attack on blood stasis.When blood stasis is eliminated,new blood will be generated,ultimately achieving the goal of supporting the right Qi without leaving blood stasis,and removing blood stasis without damaging the right Qi.This formula is suitable for the late stage of deficiency and fatigue,as it can treat the deficiency syndrome due to blood stasis due.Therefore,it has a dual effect of nourishing the body and eliminating evil spirits.In the aspect of clinical application,there are few reports on the treatment of related diseases with Dahuang Zhechong Pill alone,and most of them are added or subtracted,or combined with other prescriptions or Western medicine,treating liver,heart,lung,kidney,gynecology,andrology and other diseases.In the experimental research,Dahuang Zhechong Pill has the effects of anti-inflammation,anti-fibrosis,improving blood sugar,improving blood lipid,improving blood vessel function,improving microcirculation and so on.Therefore,its material basis research is relatively weak.In this paper,the clinical application and experimental research of Dahuang Zhuchong Pill in recent ten years were reviewed and summarized,which provided reference for further research and application of Dahuang Zhuchong Pill.