联合辛麻颗粒对慢性阻塞性肺疾病急性加重期外寒内饮证患者临床疗效和免疫功能的影响

Effect of Combined Xinma Granules on Clinical Efficacy and Immune Function of Patients with Syndrome of External Cold and Internal Fluid Retention During Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的观察慢性阻塞性肺疾病急性加重期外寒内饮证患者联合辛麻颗粒治疗的临床疗效。方法选择2023年8月至2024年4月收治的60例慢性阻塞性肺疾病急性加重期外寒内饮证患者,根据治疗方法分为对照组(n=30)和观察组(n=30)。对照组采用常规西药治疗,观察组采用常规西药联合辛麻颗粒治疗。比较2组临床疗效、血气分析[动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、血氧饱和度(SaO_(2))]、免疫指标及不良反应。结果2组总有效率观察组96.67%(29/30)高于对照组73.33%(22/30)(P<0.05)。治疗后,观察组PaO_(2)、SaO_(2)、IgA、IgG、IgM、CD3+、CD4+、CD4+/CD8+高于对照组,PaCO_(2)、CD8+低于对照组(P<0.05)。2组不良反应发生率比较无统计学差异(P>0.05)。结论慢性阻塞性肺疾病急性加重期外寒内饮证患者采用常规西药联合辛麻颗粒治疗,对免疫功能、血气分析指标有明显的改善作用,临床疗效较好、安全性较高。

Objective To observe the clinical effect of combined Xinma granules in the treatment of patients with syndrome of external cold and internal fluid retention during acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods From August 2023 to April 2024,60 patients with syndrome of external cold and internal fluid retention during AECOPD were selected and divided into control group(n=30)and observation group(n=30)according to treatment methods.The control group was treated with conventional Western medicine,and the observation group was treated with conventional Western medicine combined with Xinma granules.The clinical efficacy,blood gas analysis[arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2)),and blood oxygen saturation(SaO_(2))],immune indexes and adverse reactions of the two groups were compared.Results The total effective rate of the observation group was 96.67%(29/30),which was higher than that of the control group[73.33%(22/30)](P<0.05).After treatment,PaO_(2),SaO_(2),IgA,IgG,IgM,CD3+,CD4+,and CD4+/CD8+in observation group were higher than those in control group,while PaCO_(2) and CD8+were lower than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Conventional Western medicine combined with Xinma granules can significantly improve the immune function and blood gas analysis indexes of patients with syndrome of external cold and internal fluid retention during AECOPD,with good clinical efficacy and safety.