紫仙丹联合阿奇霉素治疗儿童过敏性紫癜合并肺炎支原体感染的效果观察

Clinical observation of Zixian Pills combined with azithromycin in the treatment of children with henoch-schonlein purpura complicated with Mycoplasma pneumoniae infection

目的探讨过敏性紫癜(HSP)合并肺炎支原体感染的患儿应用紫仙丹联合阿奇霉素治疗的疗效及安全性。方法选取安徽中医药大学第一附属医院儿科病房2021年1月—2024年2月接诊的100例儿童过敏性紫癜合并肺炎支原体感染的患儿,按照随机数字表法分为观察组(50例)和对照组(50例)。对照组给予阿奇霉素和HSP基础治疗,观察组在对照组的基础上给予中药紫仙丹口服,均治疗7~14 d。评估2组中医证候积分改善情况、临床疗效、用药不良反应,检测尿红细胞、尿微量白蛋白及尿β2-微球蛋白水平。结果治疗前2组中医证候积分比较,差异无统计学意义(P>0.05);治疗后2组中医证候积分均低于治疗前(P<0.05);治疗后2组中医证候积分比较,观察组[1.00(1.00,2.00)分]低于对照组[2.00(1.00,2.00)分,P<0.05]。2组总有效率比较,观察组优于对照组[92.0%(46/50)vs.76.0%(38/50),P<0.05]。治疗前2组尿红细胞、尿微量白蛋白、尿β2微球蛋白比较,差异均无统计学意义(P>0.05);治疗后2组尿红细胞、尿微量白蛋白、尿β2微球蛋白比较,差异均有统计学意义(P<0.05)。2组用药不良反应发生率比较,差异无统计学意义(P>0.05)。结论紫仙丹联合阿奇霉治疗儿童过敏性紫癜合并肺炎支原体感染在改善中医证候积分及减轻肾脏损害方面均有明显的效果,且具有良好的安全性。

Objective To investigate the efficacy and safety of Zixian Pills combined with azithromycin in the treatment of Henoch-Sch nlein purpura(HSP)complicated by Mycoplasma pneumoniae infection.Methods One hundred cases of children with HSP complicated by Mycoplasma.pneumoniae infection who were treated in the pediatric ward of the First Affiliated Hospital of Anhui University of Chinese Medicine from January 2021 to February 2024 were selected.They were divided into observation group(50 cases)and control group(50 cases)according to random number table method.The control group was given azithromycin and basic treatment for HSP,and the observation group was given oral Zixian Pills on the basis treatment of the control group,both of which were treated for 7-14 days.The improvement in traditional Chinese medicine(TCM)syndrome scores,clinical efficacy and adverse drug reactions were evaluated in the two groups,and the levels of urinary red blood cells,urinary microalbumin and urinary beta 2-microglobulin were measured.Results Before treatment,there was no significant difference in TCM syndrome scores between the two groups(P>0.05);After treatment,the scores of TCM syndromes in both groups were lower than those before treatment(P<0.05);After treatment,the TCM syndrome score in the observation group[1.00(1.00,2.00)]was lower than that in the control group[2.00(1.00,2.00),P<0.05].The overall response rate(ORR)in the observation group was superior to that in the control group[92.0%(46/50)vs.76.0%(38/50),P<0.05].There was no significant difference in urinary erythrocytes,urinary microalbumin and urinary beta 2-microglobulin between the two groups before treatment(P>0.05);there were significant differences in urinary erythrocytes,urinary microalbumin and urinary beta 2-microglobulin between the two groups after treatment(P<0.05).There was no significant difference in the incidence of adverse events between the two groups(P>0.05).Conclusion The treatment of HSP complicated by Mycoplasma.pneumoniae infection in children with Zixian Pills combined with azithromycin has obvious effects on improving TCM syndrome scores and reducing renal injury,and it has good safety.